STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RAP2BRas-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). (183 aa)    
Predicted Functional Partners:
ITSN2
Intersectin 2.
   
 
 0.640
ITSN1
Intersectin 1.
    
 
 0.604
TMX4
Uncharacterized protein.
   
 
 0.526
MINK1
Misshapen like kinase 1.
   
 
 0.522
TNIK
TRAF2 and NCK-interacting protein kinase isoform 1.
   
 
 0.521
SHANK3
SH3 and multiple ankyrin repeat domains 3.
   
 
 0.509
SHANK1
Uncharacterized protein.
   
 
 0.509
GNA13
G protein subunit alpha 13.
   
 
 0.505
ANKRA2
Ankyrin repeat family A member 2.
   
 
 0.499
NCALD
Neurocalcin delta.
   
 
 0.493
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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