STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (275 aa)    
Predicted Functional Partners:
NSMCE1
NSE1 homolog, SMC5-SMC6 complex component.
    
 0.990
SMC5
AAA_23 domain-containing protein.
    
 0.990
SMC6
Structural maintenance of chromosomes protein 6 isoform X2.
    
 0.988
NSMCE4A
Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
    
 0.988
MAGEF1
MAGE family member F1.
    
 
 0.763
NKAIN1
Sodium/potassium transporting ATPase interacting 1.
      
 0.727
FANCM
FA complementation group M.
    
 
 0.694
SMC3
Structural maintenance of chromosomes protein.
    
 
 0.691
LRRCC1
Leucine rich repeat and coiled-coil centrosomal protein 1.
   
  
 0.677
SMC2
Structural maintenance of chromosomes protein.
    
 
 0.674
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.