NQO1 protein (Sus scrofa) - STRING interaction network

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Score

NQO1

Flavodoxin_2 domain-containing protein. (277 aa)

Predicted Functional Partners:

GGCX

0.927

VKORC1

0.925

VKORC1L1

0.914

ODC1

0.911

CRYZ

0.893

KEAP1

0.886

HMOX1

0.885

GCLC

0.859

GCLM

0.858

NFE2L2

0.787

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRYZ	GCLC	ENSSSCP00000040428	ENSSSCP00000001618	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	Glutamate--cysteine ligase catalytic subunit isoform X3.	0.655
CRYZ	GCLM	ENSSSCP00000040428	ENSSSCP00000040673	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	Glutamate--cysteine ligase regulatory subunit.	0.567
CRYZ	HMOX1	ENSSSCP00000040428	ENSSSCP00000066228	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.	0.768
CRYZ	KEAP1	ENSSSCP00000040428	ENSSSCP00000056325	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.694
CRYZ	NFE2L2	ENSSSCP00000040428	ENSSSCP00000064368	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	Nuclear factor, erythroid 2 like 2.	0.540
CRYZ	NQO1	ENSSSCP00000040428	ENSSSCP00000063923	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	Flavodoxin_2 domain-containing protein.	0.893
GCLC	CRYZ	ENSSSCP00000001618	ENSSSCP00000040428	Glutamate--cysteine ligase catalytic subunit isoform X3.	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	0.655
GCLC	GCLM	ENSSSCP00000001618	ENSSSCP00000040673	Glutamate--cysteine ligase catalytic subunit isoform X3.	Glutamate--cysteine ligase regulatory subunit.	0.999
GCLC	HMOX1	ENSSSCP00000001618	ENSSSCP00000066228	Glutamate--cysteine ligase catalytic subunit isoform X3.	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.	0.845
GCLC	KEAP1	ENSSSCP00000001618	ENSSSCP00000056325	Glutamate--cysteine ligase catalytic subunit isoform X3.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.841
GCLC	NFE2L2	ENSSSCP00000001618	ENSSSCP00000064368	Glutamate--cysteine ligase catalytic subunit isoform X3.	Nuclear factor, erythroid 2 like 2.	0.745
GCLC	NQO1	ENSSSCP00000001618	ENSSSCP00000063923	Glutamate--cysteine ligase catalytic subunit isoform X3.	Flavodoxin_2 domain-containing protein.	0.859
GCLM	CRYZ	ENSSSCP00000040673	ENSSSCP00000040428	Glutamate--cysteine ligase regulatory subunit.	Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity).	0.567
GCLM	GCLC	ENSSSCP00000040673	ENSSSCP00000001618	Glutamate--cysteine ligase regulatory subunit.	Glutamate--cysteine ligase catalytic subunit isoform X3.	0.999
GCLM	HMOX1	ENSSSCP00000040673	ENSSSCP00000066228	Glutamate--cysteine ligase regulatory subunit.	Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.	0.802
GCLM	KEAP1	ENSSSCP00000040673	ENSSSCP00000056325	Glutamate--cysteine ligase regulatory subunit.	Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...]	0.835
GCLM	NFE2L2	ENSSSCP00000040673	ENSSSCP00000064368	Glutamate--cysteine ligase regulatory subunit.	Nuclear factor, erythroid 2 like 2.	0.681
GCLM	NQO1	ENSSSCP00000040673	ENSSSCP00000063923	Glutamate--cysteine ligase regulatory subunit.	Flavodoxin_2 domain-containing protein.	0.858
GGCX	NQO1	ENSSSCP00000060390	ENSSSCP00000063923	Vitamin K-dependent gamma-carboxylase isoform 1.	Flavodoxin_2 domain-containing protein.	0.927
GGCX	VKORC1	ENSSSCP00000060390	ENSSSCP00000049733	Vitamin K-dependent gamma-carboxylase isoform 1.	Vitamin K epoxide reductase complex subunit 1.	0.980