| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRB1 | ARRB2 | ENSSSCP00000033134 | ENSSSCP00000060730 | Arrestin beta 1. | Arrestin beta 2. | 0.983 |
| ARRB1 | CCR2 | ENSSSCP00000033134 | ENSSSCP00000024949 | Arrestin beta 1. | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | 0.906 |
| ARRB1 | CCR9 | ENSSSCP00000033134 | ENSSSCP00000036776 | Arrestin beta 1. | Chemokine (C-C motif) receptor 9 isoform A; Belongs to the G-protein coupled receptor 1 family. | 0.857 |
| ARRB1 | CXCR4 | ENSSSCP00000033134 | ENSSSCP00000058444 | Arrestin beta 1. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.945 |
| ARRB1 | GRK3 | ENSSSCP00000033134 | ENSSSCP00000063949 | Arrestin beta 1. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.982 |
| ARRB1 | OPRM1 | ENSSSCP00000033134 | ENSSSCP00000004401 | Arrestin beta 1. | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] | 0.939 |
| ARRB1 | SMO | ENSSSCP00000033134 | ENSSSCP00000017553 | Arrestin beta 1. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.989 |
| ARRB2 | ARRB1 | ENSSSCP00000060730 | ENSSSCP00000033134 | Arrestin beta 2. | Arrestin beta 1. | 0.983 |
| ARRB2 | CCR2 | ENSSSCP00000060730 | ENSSSCP00000024949 | Arrestin beta 2. | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | 0.905 |
| ARRB2 | CCR9 | ENSSSCP00000060730 | ENSSSCP00000036776 | Arrestin beta 2. | Chemokine (C-C motif) receptor 9 isoform A; Belongs to the G-protein coupled receptor 1 family. | 0.857 |
| ARRB2 | CXCR4 | ENSSSCP00000060730 | ENSSSCP00000058444 | Arrestin beta 2. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.946 |
| ARRB2 | GRK3 | ENSSSCP00000060730 | ENSSSCP00000063949 | Arrestin beta 2. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.982 |
| ARRB2 | OPRM1 | ENSSSCP00000060730 | ENSSSCP00000004401 | Arrestin beta 2. | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...] | 0.939 |
| ARRB2 | SMO | ENSSSCP00000060730 | ENSSSCP00000017553 | Arrestin beta 2. | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.989 |
| CCR2 | ARRB1 | ENSSSCP00000024949 | ENSSSCP00000033134 | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | Arrestin beta 1. | 0.906 |
| CCR2 | ARRB2 | ENSSSCP00000024949 | ENSSSCP00000060730 | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | Arrestin beta 2. | 0.905 |
| CCR2 | CXCR4 | ENSSSCP00000024949 | ENSSSCP00000058444 | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] | 0.960 |
| CCR2 | GRK3 | ENSSSCP00000024949 | ENSSSCP00000063949 | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.931 |
| CCR9 | ARRB1 | ENSSSCP00000036776 | ENSSSCP00000033134 | Chemokine (C-C motif) receptor 9 isoform A; Belongs to the G-protein coupled receptor 1 family. | Arrestin beta 1. | 0.857 |
| CCR9 | ARRB2 | ENSSSCP00000036776 | ENSSSCP00000060730 | Chemokine (C-C motif) receptor 9 isoform A; Belongs to the G-protein coupled receptor 1 family. | Arrestin beta 2. | 0.857 |
