STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AAR2AAR2 splicing factor. (402 aa)    
Predicted Functional Partners:
PRPF8
Pre-mRNA processing factor 8.
    
 
 0.976
EFTUD2
116 kDa U5 small nuclear ribonucleoprotein component.
    
 
 0.903
TSSC4
Tumor suppressing subtransferable candidate 4.
    
 
 0.863
ECD
Ecdysoneless cell cycle regulator.
    
 
 0.837
SNRNP200
U5 small nuclear ribonucleoprotein 200 kDa helicase isoform X1.
    
 
 0.828
NEK6
Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence [...]
      
 0.794
ZNHIT2
Zinc finger HIT-type containing 2.
    
 
 0.793
EAPP
E2F-associated phosphoprotein isoform 1.
    
 
 0.792
CD2BP2
CD2 cytoplasmic tail binding protein 2.
   
 
 0.779
SNRNP40
Small nuclear ribonucleoprotein U5 subunit 40.
   
 
 0.752
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.