node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPS6 | COPS7A | ENSSSCP00000041142 | ENSSSCP00000000737 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | COP9 signalosome subunit 7A. | 0.989 |
COPS6 | GIGYF1 | ENSSSCP00000041142 | ENSSSCP00000008189 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | GRB10 interacting GYF protein 1. | 0.729 |
COPS6 | GNB2 | ENSSSCP00000041142 | ENSSSCP00000008190 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | G protein subunit beta 2. | 0.563 |
COPS6 | MICALL2 | ENSSSCP00000041142 | ENSSSCP00000008070 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | MICAL-like protein 2 isoform X1. | 0.485 |
COPS6 | TSC22D4 | ENSSSCP00000041142 | ENSSSCP00000064554 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | TSC22 domain family member 4. | 0.765 |
COPS7A | COPS6 | ENSSSCP00000000737 | ENSSSCP00000041142 | COP9 signalosome subunit 7A. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.989 |
COPS7A | GIGYF1 | ENSSSCP00000000737 | ENSSSCP00000008189 | COP9 signalosome subunit 7A. | GRB10 interacting GYF protein 1. | 0.453 |
COPS7A | MICALL2 | ENSSSCP00000000737 | ENSSSCP00000008070 | COP9 signalosome subunit 7A. | MICAL-like protein 2 isoform X1. | 0.544 |
COPS7A | TSC22D4 | ENSSSCP00000000737 | ENSSSCP00000064554 | COP9 signalosome subunit 7A. | TSC22 domain family member 4. | 0.504 |
GIGYF1 | COPS6 | ENSSSCP00000008189 | ENSSSCP00000041142 | GRB10 interacting GYF protein 1. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.729 |
GIGYF1 | COPS7A | ENSSSCP00000008189 | ENSSSCP00000000737 | GRB10 interacting GYF protein 1. | COP9 signalosome subunit 7A. | 0.453 |
GIGYF1 | GNB2 | ENSSSCP00000008189 | ENSSSCP00000008190 | GRB10 interacting GYF protein 1. | G protein subunit beta 2. | 0.610 |
GIGYF1 | MICALL2 | ENSSSCP00000008189 | ENSSSCP00000008070 | GRB10 interacting GYF protein 1. | MICAL-like protein 2 isoform X1. | 0.510 |
GIGYF1 | TSC22D4 | ENSSSCP00000008189 | ENSSSCP00000064554 | GRB10 interacting GYF protein 1. | TSC22 domain family member 4. | 0.779 |
GNB2 | COPS6 | ENSSSCP00000008190 | ENSSSCP00000041142 | G protein subunit beta 2. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.563 |
GNB2 | GIGYF1 | ENSSSCP00000008190 | ENSSSCP00000008189 | G protein subunit beta 2. | GRB10 interacting GYF protein 1. | 0.610 |
GNB2 | TSC22D4 | ENSSSCP00000008190 | ENSSSCP00000064554 | G protein subunit beta 2. | TSC22 domain family member 4. | 0.629 |
MICALL2 | COPS6 | ENSSSCP00000008070 | ENSSSCP00000041142 | MICAL-like protein 2 isoform X1. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.485 |
MICALL2 | COPS7A | ENSSSCP00000008070 | ENSSSCP00000000737 | MICAL-like protein 2 isoform X1. | COP9 signalosome subunit 7A. | 0.544 |
MICALL2 | GIGYF1 | ENSSSCP00000008070 | ENSSSCP00000008189 | MICAL-like protein 2 isoform X1. | GRB10 interacting GYF protein 1. | 0.510 |