STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)    
Predicted Functional Partners:
PSMA5
Proteasome endopeptidase complex; Belongs to the peptidase T1A family.
   
 0.999
PSMD12
26S proteasome non-ATPase regulatory subunit 12 isoform 1.
   
 0.999
PSMC1
26S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family.
  
0.998
PSMD4
Proteasome 26S subunit, non-ATPase 4.
   
 0.998
PSMD6
Proteasome 26S subunit, non-ATPase 6.
   
 0.998
PSMC2
AAA domain-containing protein; Belongs to the AAA ATPase family.
  
0.998
PSMD11
Proteasome 26S subunit, non-ATPase 11.
   
 0.998
PSMD7
Proteasome 26S subunit, non-ATPase 7.
   
 0.998
PSMC4
Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family.
  
0.998
PSMD14
26S proteasome non-ATPase regulatory subunit 14.
   
 0.998
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.