node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC42 | GSK3B | ENSSSCP00000029815 | ENSSSCP00000046229 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.611 |
CDC42 | PARD3 | ENSSSCP00000029815 | ENSSSCP00000063272 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Par-3 family cell polarity regulator. | 0.953 |
CDC42 | PARD6A | ENSSSCP00000029815 | ENSSSCP00000067234 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Par-6 family cell polarity regulator alpha. | 0.981 |
CDC42 | PARD6B | ENSSSCP00000029815 | ENSSSCP00000036345 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Uncharacterized protein. | 0.981 |
CDC42 | PRKCI | ENSSSCP00000029815 | ENSSSCP00000012516 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.936 |
CDC42 | PRKCZ | ENSSSCP00000029815 | ENSSSCP00000027683 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.939 |
CDC42 | RAC2 | ENSSSCP00000029815 | ENSSSCP00000070230 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rac family small GTPase 2. | 0.931 |
CDC42 | RAC3 | ENSSSCP00000029815 | ENSSSCP00000047362 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rac family small GTPase 3. | 0.929 |
DVL2 | GSK3B | ENSSSCP00000019910 | ENSSSCP00000046229 | Dishevelled segment polarity protein 2. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.953 |
DVL2 | PARD6A | ENSSSCP00000019910 | ENSSSCP00000067234 | Dishevelled segment polarity protein 2. | Par-6 family cell polarity regulator alpha. | 0.913 |
DVL2 | RAC2 | ENSSSCP00000019910 | ENSSSCP00000070230 | Dishevelled segment polarity protein 2. | Rac family small GTPase 2. | 0.541 |
DVL2 | RAC3 | ENSSSCP00000019910 | ENSSSCP00000047362 | Dishevelled segment polarity protein 2. | Rac family small GTPase 3. | 0.647 |
GSK3B | CDC42 | ENSSSCP00000046229 | ENSSSCP00000029815 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.611 |
GSK3B | DVL2 | ENSSSCP00000046229 | ENSSSCP00000019910 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Dishevelled segment polarity protein 2. | 0.953 |
GSK3B | PARD3 | ENSSSCP00000046229 | ENSSSCP00000063272 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Par-3 family cell polarity regulator. | 0.910 |
GSK3B | PARD6A | ENSSSCP00000046229 | ENSSSCP00000067234 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Par-6 family cell polarity regulator alpha. | 0.914 |
GSK3B | PARD6B | ENSSSCP00000046229 | ENSSSCP00000036345 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Uncharacterized protein. | 0.913 |
GSK3B | PRKCZ | ENSSSCP00000046229 | ENSSSCP00000027683 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.915 |
MPP5 | PARD3 | ENSSSCP00000002484 | ENSSSCP00000063272 | MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. | Par-3 family cell polarity regulator. | 0.523 |
MPP5 | PARD6A | ENSSSCP00000002484 | ENSSSCP00000067234 | MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. | Par-6 family cell polarity regulator alpha. | 0.943 |