STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TIMP2Uncharacterized protein. (257 aa)    
Predicted Functional Partners:
MMP14
Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...]
   
 0.999
MMP13
Matrix metallopeptidase 13.
   
 
 0.989
MMP2
Uncharacterized protein.
   
 0.949
MMP1
Stromelysin-1 preproprotein.
   
 
 0.936
MMP9
Matrix metalloproteinase-9.
   
 
 0.920
MMP15
Matrix metallopeptidase 15.
   
 0.905
MMP16
Matrix metalloproteinase-16.
   
 0.879
MMP17
Matrix metalloproteinase-17 preproprotein.
   
 0.842
MMP24
Matrix metallopeptidase 24.
   
 0.800
MMP8
Matrix metallopeptidase 8.
   
 
 0.795
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.