STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TTKTTK protein kinase. (947 aa)    
Predicted Functional Partners:
NDC80
NDC80 kinetochore complex component.
   
 
 0.991
MAD1L1
Mitotic arrest deficient 1 like 1.
    
 0.978
NUF2
NUF2 component of NDC80 kinetochore complex.
   
 
 0.966
KIF11
Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
 
 0.965
BUB1B
BUB1 N-terminal domain-containing protein.
   
 
 0.965
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 
 0.964
MAD2L1
Mitotic arrest deficient 2 like 1.
   
 
 0.962
DLGAP5
DLG associated protein 5.
   
  
 0.955
TOP2A
DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.
   
  
 0.951
ASPM
Abnormal spindle microtubule assembly.
   
  
 0.940
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.