STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
   
 0.998
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.927
GRB2
Growth factor receptor-bound protein 2 isoform 1.
    
 0.884
CBLB
E3 ubiquitin-protein ligase CBL-B isoform X1.
    
 
 0.759
TMEM184B
Transmembrane protein 184B.
    
 
 0.689
DOK4
Docking protein 4.
    
 
 0.689
EGFR
Receptor protein-tyrosine kinase.
   
 0.682
ADAMTSL5
ADAMTS-like protein 5 isoform X2.
   
  
 0.677
PKP4
Plakophilin 4.
   
  
 0.634
SPRY1
Sprouty RTK signaling antagonist 1.
  
0.586
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.