STK39 protein (Sus scrofa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

STK39

Serine/threonine kinase 39. (582 aa)

Predicted Functional Partners:

SEC61G

0.872

SEC62

0.867

SEC63

0.742

SEC61B

0.731

SEC61A1

0.696

SEC61A2

0.696

CERS6

0.610

SLC12A1

0.604

SLC12A2

0.586

SLC12A3

0.575

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CERS6	STK39	ENSSSCP00000052932	ENSSSCP00000070418	Ceramide synthase 6.	Serine/threonine kinase 39.	0.610
SEC61A1	SEC61A2	ENSSSCP00000049118	ENSSSCP00000067538	SEC61 translocon alpha 1 subunit.	SEC61 translocon alpha 2 subunit.	0.903
SEC61A1	SEC61B	ENSSSCP00000049118	ENSSSCP00000005777	SEC61 translocon alpha 1 subunit.	Uncharacterized protein.	0.999
SEC61A1	SEC61G	ENSSSCP00000049118	ENSSSCP00000050012	SEC61 translocon alpha 1 subunit.	SEC61 translocon gamma subunit.	0.999
SEC61A1	SEC62	ENSSSCP00000049118	ENSSSCP00000025606	SEC61 translocon alpha 1 subunit.	Translocation protein SEC62.	0.882
SEC61A1	SEC63	ENSSSCP00000049118	ENSSSCP00000004730	SEC61 translocon alpha 1 subunit.	SEC63 homolog, protein translocation regulator.	0.988
SEC61A1	STK39	ENSSSCP00000049118	ENSSSCP00000070418	SEC61 translocon alpha 1 subunit.	Serine/threonine kinase 39.	0.696
SEC61A2	SEC61A1	ENSSSCP00000067538	ENSSSCP00000049118	SEC61 translocon alpha 2 subunit.	SEC61 translocon alpha 1 subunit.	0.903
SEC61A2	SEC61B	ENSSSCP00000067538	ENSSSCP00000005777	SEC61 translocon alpha 2 subunit.	Uncharacterized protein.	0.988
SEC61A2	SEC61G	ENSSSCP00000067538	ENSSSCP00000050012	SEC61 translocon alpha 2 subunit.	SEC61 translocon gamma subunit.	0.986
SEC61A2	SEC62	ENSSSCP00000067538	ENSSSCP00000025606	SEC61 translocon alpha 2 subunit.	Translocation protein SEC62.	0.872
SEC61A2	SEC63	ENSSSCP00000067538	ENSSSCP00000004730	SEC61 translocon alpha 2 subunit.	SEC63 homolog, protein translocation regulator.	0.988
SEC61A2	STK39	ENSSSCP00000067538	ENSSSCP00000070418	SEC61 translocon alpha 2 subunit.	Serine/threonine kinase 39.	0.696
SEC61B	SEC61A1	ENSSSCP00000005777	ENSSSCP00000049118	Uncharacterized protein.	SEC61 translocon alpha 1 subunit.	0.999
SEC61B	SEC61A2	ENSSSCP00000005777	ENSSSCP00000067538	Uncharacterized protein.	SEC61 translocon alpha 2 subunit.	0.988
SEC61B	SEC61G	ENSSSCP00000005777	ENSSSCP00000050012	Uncharacterized protein.	SEC61 translocon gamma subunit.	0.999
SEC61B	SEC62	ENSSSCP00000005777	ENSSSCP00000025606	Uncharacterized protein.	Translocation protein SEC62.	0.895
SEC61B	SEC63	ENSSSCP00000005777	ENSSSCP00000004730	Uncharacterized protein.	SEC63 homolog, protein translocation regulator.	0.994
SEC61B	STK39	ENSSSCP00000005777	ENSSSCP00000070418	Uncharacterized protein.	Serine/threonine kinase 39.	0.731
SEC61G	SEC61A1	ENSSSCP00000050012	ENSSSCP00000049118	SEC61 translocon gamma subunit.	SEC61 translocon alpha 1 subunit.	0.999

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006487

Protein N-linked glycosylation

10 of 65

2.52

9.43

4.95e-21

GO:0018279

Protein N-linked glycosylation via asparagine

5 of 15

2.85

5.35

9.42e-11

GO:0043686

Co-translational protein modification

3 of 4

3.21

3.27

1.18e-06

GO:0006516

Glycoprotein catabolic process

2 of 16

2.43

1.13

0.0085

GO:0043687

Post-translational protein modification

2 of 27

2.2

0.9

0.0214

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004579

Dolichyl-diphosphooligosaccharide-protein glycotransferase activity

3 of 3

3.33

2.99

3.97e-06

GO:0015095

Magnesium ion transmembrane transporter activity

2 of 12

2.55

0.99

0.0158

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008250

Oligosaccharyltransferase complex

10 of 14

3.19

14.12

1.82e-27

GO:0005789

Endoplasmic reticulum membrane

11 of 867

1.43

2.84

7.37e-14

GO:0034998

Oligosaccharyltransferase I complex

2 of 3

3.16

2.12

0.00015

GO:0016021

Integral component of membrane

11 of 5741

0.61

0.55

1.71e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38234833

(2023) Gene module reconstruction elucidates cellular differentiation processes and the regulatory logic of specialized secretion.

3 of 50

2.11

1.06

0.0101

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8194

Oligosaccharyltransferase complex

10 of 14

3.19

14.05

2.45e-27

CL:8190

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

11 of 30

2.9

13.68

5.03e-28

CL:8199

Oligosaccharyltransferase complex

5 of 5

3.33

6.5

1.37e-12

CL:8212

Oligosaccharyltransferase complex

2 of 5

2.93

1.43

0.0026

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola00513

Various types of N-glycan biosynthesis

8 of 42

2.61

8.44

6.12e-18

ola00510

N-Glycan biosynthesis

8 of 54

2.5

7.96

1.92e-17

ola04141

Protein processing in endoplasmic reticulum

9 of 170

2.06

6.03

2.03e-16

ola01100

Metabolic pathways

8 of 1552

1.04

1.18

2.04e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5663205

Infectious disease

7 of 100

2.18

4.86

1.74e-11

MAP-1643685

Disease

7 of 177

1.93

3.84

4.15e-10

MAP-446203

Asparagine N-linked glycosylation

7 of 433

1.54

2.33

1.28e-07

MAP-5223345

Miscellaneous transport and binding events

2 of 31

2.14

0.83

0.0286

MAP-597592

Post-translational protein modification

7 of 2150

0.84

0.62

0.0052

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008250

Oligosaccharyltransferase complex

10 of 16

3.13

13.75

6.08e-27

GOCC:0005789

Endoplasmic reticulum membrane

11 of 318

1.87

5.53

2.51e-18

GOCC:0005783

Endoplasmic reticulum

11 of 610

1.59

3.67

1.47e-15

GOCC:0098796

Membrane protein complex

11 of 1010

1.37

2.54

2.90e-13

GOCC:0034998

Oligosaccharyltransferase I complex

2 of 5

2.93

1.84

0.00046

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

5 of 105

2.01

3.01

3.03e-07

KW-1133

Transmembrane helix

10 of 5485

0.59

0.48

0.00067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02516

Oligosaccharyl transferase STT3 subunit

2 of 2

3.33

1.43

0.0027

PF02109

DAD family

2 of 2

3.33

1.43

0.0027

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003674

Oligosaccharyl transferase, STT3 subunit

3 of 3

3.33

2.75

1.08e-05

IPR003038

DAD/Ost2

2 of 2

3.33

1.32

0.0042

IPR021149

Oligosaccharyl transferase complex, subunit OST3/OST6

2 of 3

3.16

1.29

0.0047

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