node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRMS1 | HPN | ENSSSCP00000056392 | ENSSSCP00000070838 | BRMS1 transcriptional repressor and anoikis regulator. | Hepsin; Belongs to the peptidase S1 family. | 0.524 |
EIF2S1 | HPN | ENSSSCP00000037333 | ENSSSCP00000070838 | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] | Hepsin; Belongs to the peptidase S1 family. | 0.524 |
HGF | HPN | ENSSSCP00000016330 | ENSSSCP00000070838 | Hepatocyte growth factor; Belongs to the peptidase S1 family. | Hepsin; Belongs to the peptidase S1 family. | 0.788 |
HGF | MET | ENSSSCP00000016330 | ENSSSCP00000017620 | Hepatocyte growth factor; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.999 |
HGF | SPINT1 | ENSSSCP00000016330 | ENSSSCP00000054184 | Hepatocyte growth factor; Belongs to the peptidase S1 family. | Serine peptidase inhibitor, Kunitz type 1. | 0.826 |
HPN | BRMS1 | ENSSSCP00000070838 | ENSSSCP00000056392 | Hepsin; Belongs to the peptidase S1 family. | BRMS1 transcriptional repressor and anoikis regulator. | 0.524 |
HPN | EIF2S1 | ENSSSCP00000070838 | ENSSSCP00000037333 | Hepsin; Belongs to the peptidase S1 family. | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] | 0.524 |
HPN | HGF | ENSSSCP00000070838 | ENSSSCP00000016330 | Hepsin; Belongs to the peptidase S1 family. | Hepatocyte growth factor; Belongs to the peptidase S1 family. | 0.788 |
HPN | LOC100523213 | ENSSSCP00000070838 | ENSSSCP00000010750 | Hepsin; Belongs to the peptidase S1 family. | Ig-like domain-containing protein. | 0.690 |
HPN | MET | ENSSSCP00000070838 | ENSSSCP00000017620 | Hepsin; Belongs to the peptidase S1 family. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.501 |
HPN | MMP19 | ENSSSCP00000070838 | ENSSSCP00000000385 | Hepsin; Belongs to the peptidase S1 family. | Matrix metallopeptidase 19. | 0.492 |
HPN | MST1 | ENSSSCP00000070838 | ENSSSCP00000012139 | Hepsin; Belongs to the peptidase S1 family. | Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.803 |
HPN | SERPINA5 | ENSSSCP00000070838 | ENSSSCP00000040778 | Hepsin; Belongs to the peptidase S1 family. | Plasma serine protease inhibitor preproprotein; Belongs to the serpin family. | 0.541 |
HPN | SPINT1 | ENSSSCP00000070838 | ENSSSCP00000054184 | Hepsin; Belongs to the peptidase S1 family. | Serine peptidase inhibitor, Kunitz type 1. | 0.510 |
HPN | UMOD | ENSSSCP00000070838 | ENSSSCP00000008389 | Hepsin; Belongs to the peptidase S1 family. | Uromodulin. | 0.599 |
LOC100523213 | HPN | ENSSSCP00000010750 | ENSSSCP00000070838 | Ig-like domain-containing protein. | Hepsin; Belongs to the peptidase S1 family. | 0.690 |
MET | HGF | ENSSSCP00000017620 | ENSSSCP00000016330 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Hepatocyte growth factor; Belongs to the peptidase S1 family. | 0.999 |
MET | HPN | ENSSSCP00000017620 | ENSSSCP00000070838 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Hepsin; Belongs to the peptidase S1 family. | 0.501 |
MET | MST1 | ENSSSCP00000017620 | ENSSSCP00000012139 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.654 |
MMP19 | HPN | ENSSSCP00000000385 | ENSSSCP00000070838 | Matrix metallopeptidase 19. | Hepsin; Belongs to the peptidase S1 family. | 0.492 |