STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EMCNEndomucin. (246 aa)    
Predicted Functional Partners:
NAF1
Nuclear assembly factor 1 ribonucleoprotein.
      
 0.778
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
  
 0.738
LYVE1
Lymphatic vessel endothelial hyaluronic acid receptor 1 isoform X2.
   
  
 0.723
PDGFB
Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.
      
 0.719
ROBO4
Roundabout guidance receptor 4.
   
  
 0.701
CDH5
Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...]
   
  
 0.698
PECAM1
Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...]
   
  
 0.689
TESMIN
Testis expressed metallothionein like protein.
      
 0.666
ADGRF5
Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.662
APLNR
Apelin receptor; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.653
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (26%) [HD]