STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITFG2Integrin alpha FG-GAP repeat containing 2. (455 aa)    
Predicted Functional Partners:
KPTN
Kaptin, actin binding protein.
    
 0.999
C12orf66
Chromosome 12 open reading frame 66.
    
 0.999
SZT2
SZT2 subunit of KICSTOR complex.
    
 0.998
DEPDC5
DEP domain-containing protein.
    
 0.991
WDR24
GATOR complex protein WDR24.
    
 0.989
WDR59
WD repeat domain 59.
    
 0.987
LAMP1
Uncharacterized protein.
    
   0.951
BMT2
S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]
    
 0.876
NPRL3
NPR3 like, GATOR1 complex subunit.
   
 0.808
MIOS
Meiosis regulator for oocyte development.
     
 0.807
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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