node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMT2 | C12orf66 | ENSSSCP00000051911 | ENSSSCP00000042352 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Chromosome 12 open reading frame 66. | 0.906 |
BMT2 | DEPDC5 | ENSSSCP00000051911 | ENSSSCP00000041590 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | DEP domain-containing protein. | 0.839 |
BMT2 | ITFG2 | ENSSSCP00000051911 | ENSSSCP00000073367 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Integrin alpha FG-GAP repeat containing 2. | 0.876 |
BMT2 | KPTN | ENSSSCP00000051911 | ENSSSCP00000032873 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Kaptin, actin binding protein. | 0.801 |
BMT2 | MIOS | ENSSSCP00000051911 | ENSSSCP00000024155 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | Meiosis regulator for oocyte development. | 0.501 |
BMT2 | NPRL3 | ENSSSCP00000051911 | ENSSSCP00000008520 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | NPR3 like, GATOR1 complex subunit. | 0.758 |
BMT2 | SZT2 | ENSSSCP00000051911 | ENSSSCP00000041337 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | SZT2 subunit of KICSTOR complex. | 0.798 |
BMT2 | WDR24 | ENSSSCP00000051911 | ENSSSCP00000008551 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | GATOR complex protein WDR24. | 0.517 |
BMT2 | WDR59 | ENSSSCP00000051911 | ENSSSCP00000040235 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | WD repeat domain 59. | 0.430 |
C12orf66 | BMT2 | ENSSSCP00000042352 | ENSSSCP00000051911 | Chromosome 12 open reading frame 66. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.906 |
C12orf66 | DEPDC5 | ENSSSCP00000042352 | ENSSSCP00000041590 | Chromosome 12 open reading frame 66. | DEP domain-containing protein. | 0.994 |
C12orf66 | ITFG2 | ENSSSCP00000042352 | ENSSSCP00000073367 | Chromosome 12 open reading frame 66. | Integrin alpha FG-GAP repeat containing 2. | 0.999 |
C12orf66 | KPTN | ENSSSCP00000042352 | ENSSSCP00000032873 | Chromosome 12 open reading frame 66. | Kaptin, actin binding protein. | 0.998 |
C12orf66 | MIOS | ENSSSCP00000042352 | ENSSSCP00000024155 | Chromosome 12 open reading frame 66. | Meiosis regulator for oocyte development. | 0.833 |
C12orf66 | NPRL3 | ENSSSCP00000042352 | ENSSSCP00000008520 | Chromosome 12 open reading frame 66. | NPR3 like, GATOR1 complex subunit. | 0.855 |
C12orf66 | SZT2 | ENSSSCP00000042352 | ENSSSCP00000041337 | Chromosome 12 open reading frame 66. | SZT2 subunit of KICSTOR complex. | 0.998 |
C12orf66 | WDR24 | ENSSSCP00000042352 | ENSSSCP00000008551 | Chromosome 12 open reading frame 66. | GATOR complex protein WDR24. | 0.990 |
C12orf66 | WDR59 | ENSSSCP00000042352 | ENSSSCP00000040235 | Chromosome 12 open reading frame 66. | WD repeat domain 59. | 0.987 |
DEPDC5 | BMT2 | ENSSSCP00000041590 | ENSSSCP00000051911 | DEP domain-containing protein. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.839 |
DEPDC5 | C12orf66 | ENSSSCP00000041590 | ENSSSCP00000042352 | DEP domain-containing protein. | Chromosome 12 open reading frame 66. | 0.994 |