| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRCA1 | EP300 | ENSSSCP00000034439 | ENSSSCP00000020812 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | E1A binding protein p300. | 0.937 |
| BRCA1 | MYC | ENSSSCP00000034439 | ENSSSCP00000074218 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.969 |
| BRCA1 | SKP2 | ENSSSCP00000034439 | ENSSSCP00000017834 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | S-phase kinase-associated protein 2 isoform 1. | 0.690 |
| EP300 | BRCA1 | ENSSSCP00000020812 | ENSSSCP00000034439 | E1A binding protein p300. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.937 |
| EP300 | MAPK1 | ENSSSCP00000020812 | ENSSSCP00000073842 | E1A binding protein p300. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.612 |
| EP300 | MAPK3 | ENSSSCP00000020812 | ENSSSCP00000057520 | E1A binding protein p300. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.612 |
| EP300 | MAX | ENSSSCP00000020812 | ENSSSCP00000049597 | E1A binding protein p300. | MYC associated factor X. | 0.773 |
| EP300 | MYC | ENSSSCP00000020812 | ENSSSCP00000074218 | E1A binding protein p300. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.952 |
| EP300 | SKP2 | ENSSSCP00000020812 | ENSSSCP00000017834 | E1A binding protein p300. | S-phase kinase-associated protein 2 isoform 1. | 0.818 |
| EP300 | ZBTB17 | ENSSSCP00000020812 | ENSSSCP00000074366 | E1A binding protein p300. | Zinc finger and BTB domain containing 17. | 0.611 |
| FBXW7 | GSK3B | ENSSSCP00000022261 | ENSSSCP00000046229 | F-box and WD repeat domain containing 7. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.498 |
| FBXW7 | MAPK1 | ENSSSCP00000022261 | ENSSSCP00000073842 | F-box and WD repeat domain containing 7. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.474 |
| FBXW7 | MAPK3 | ENSSSCP00000022261 | ENSSSCP00000057520 | F-box and WD repeat domain containing 7. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.473 |
| FBXW7 | MAX | ENSSSCP00000022261 | ENSSSCP00000049597 | F-box and WD repeat domain containing 7. | MYC associated factor X. | 0.515 |
| FBXW7 | MYC | ENSSSCP00000022261 | ENSSSCP00000074218 | F-box and WD repeat domain containing 7. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.965 |
| FBXW7 | SKP2 | ENSSSCP00000022261 | ENSSSCP00000017834 | F-box and WD repeat domain containing 7. | S-phase kinase-associated protein 2 isoform 1. | 0.954 |
| FBXW7 | USP28 | ENSSSCP00000022261 | ENSSSCP00000049690 | F-box and WD repeat domain containing 7. | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. | 0.688 |
| GSK3B | FBXW7 | ENSSSCP00000046229 | ENSSSCP00000022261 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | F-box and WD repeat domain containing 7. | 0.498 |
| GSK3B | MYC | ENSSSCP00000046229 | ENSSSCP00000074218 | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.986 |
| MAPK1 | EP300 | ENSSSCP00000073842 | ENSSSCP00000020812 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | E1A binding protein p300. | 0.612 |
