node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL74802.1 | SHL75363.1 | SAMN05443543_104234 | SAMN05443543_104265 | 2TM domain-containing protein. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.682 |
SHL74802.1 | dfrA | SAMN05443543_104234 | SAMN05443543_104233 | 2TM domain-containing protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.922 |
SHL74802.1 | fmt | SAMN05443543_104234 | SAMN05443543_105270 | 2TM domain-containing protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.700 |
SHL74802.1 | folC | SAMN05443543_104234 | SAMN05443543_10819 | 2TM domain-containing protein. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.686 |
SHL74802.1 | gcvP | SAMN05443543_104234 | SAMN05443543_10839 | 2TM domain-containing protein. | Glycine dehydrogenase; Belongs to the GcvP family. | 0.689 |
SHL74802.1 | gcvT | SAMN05443543_104234 | SAMN05443543_1126 | 2TM domain-containing protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.686 |
SHL74802.1 | glyA | SAMN05443543_104234 | SAMN05443543_10573 | 2TM domain-containing protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.698 |
SHL74802.1 | purH | SAMN05443543_104234 | SAMN05443543_104221 | 2TM domain-containing protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.688 |
SHL74802.1 | purN | SAMN05443543_104234 | SAMN05443543_102149 | 2TM domain-containing protein. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.688 |
SHL74802.1 | thyA | SAMN05443543_104234 | SAMN05443543_104236 | 2TM domain-containing protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.898 |
SHL75363.1 | SHL74802.1 | SAMN05443543_104265 | SAMN05443543_104234 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 2TM domain-containing protein. | 0.682 |
SHL75363.1 | dfrA | SAMN05443543_104265 | SAMN05443543_104233 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.903 |
SHL75363.1 | fmt | SAMN05443543_104265 | SAMN05443543_105270 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.904 |
SHL75363.1 | folC | SAMN05443543_104265 | SAMN05443543_10819 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.591 |
SHL75363.1 | gcvP | SAMN05443543_104265 | SAMN05443543_10839 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine dehydrogenase; Belongs to the GcvP family. | 0.929 |
SHL75363.1 | gcvT | SAMN05443543_104265 | SAMN05443543_1126 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.926 |
SHL75363.1 | glyA | SAMN05443543_104265 | SAMN05443543_10573 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
SHL75363.1 | purH | SAMN05443543_104265 | SAMN05443543_104221 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.906 |
SHL75363.1 | purN | SAMN05443543_104265 | SAMN05443543_102149 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.909 |
SHL75363.1 | thyA | SAMN05443543_104265 | SAMN05443543_104236 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.513 |