AG1IA_01558 protein (Rhizoctonia solani AG1IA)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AG1IA_01558

Translin domain-containing protein. (302 aa)

Predicted Functional Partners:

AG1IA_01322

0.999

AG1IA_08233

0.738

AG1IA_06467

0.738

AG1IA_04679

0.738

AG1IA_00145

0.738

AG1IA_06462

0.726

AG1IA_01379

0.675

AG1IA_05661

0.613

AG1IA_00283

0.602

AG1IA_06973

0.555

Your Current Organism:

Rhizoctonia solani AG1IA

NCBI taxonomy Id: 983506
Other names: R. solani AG-1 IA, Rhizoctonia solani AG-1 IA, Rhizoctonia solani AG-1IA, Rhizoctonia solani AG-1IA SC, Rhizoctonia solani AG1 IA, Rhizoctonia solani AG1 IA SC, Rhizoctonia solani AG1-IA

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AG1IA_00145	AG1IA_01322	L8XAX8	L8X347	Piwi domain-containing protein.	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	0.744
AG1IA_00145	AG1IA_01558	L8XAX8	L8X5P3	Piwi domain-containing protein.	Translin domain-containing protein.	0.738
AG1IA_00283	AG1IA_01558	L8XAH6	L8X5P3	Developmentally regulated GTP binding protein 1.	Translin domain-containing protein.	0.602
AG1IA_01322	AG1IA_00145	L8X347	L8XAX8	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	Piwi domain-containing protein.	0.744
AG1IA_01322	AG1IA_01558	L8X347	L8X5P3	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	Translin domain-containing protein.	0.999
AG1IA_01322	AG1IA_04679	L8X347	L8WT70	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	Argonaute-like protein; Belongs to the argonaute family.	0.744
AG1IA_01322	AG1IA_06462	L8X347	L8WRZ3	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	ArgoN domain-containing protein.	0.744
AG1IA_01322	AG1IA_06467	L8X347	L8WRY9	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	Piwi domain-containing protein.	0.744
AG1IA_01322	AG1IA_08233	L8X347	L8WLP4	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	Argonaute-like protein.	0.744
AG1IA_01379	AG1IA_01558	L8X658	L8X5P3	Nuclear cap-binding protein subunit 2.	Translin domain-containing protein.	0.675
AG1IA_01558	AG1IA_00145	L8X5P3	L8XAX8	Translin domain-containing protein.	Piwi domain-containing protein.	0.738
AG1IA_01558	AG1IA_00283	L8X5P3	L8XAH6	Translin domain-containing protein.	Developmentally regulated GTP binding protein 1.	0.602
AG1IA_01558	AG1IA_01322	L8X5P3	L8X347	Translin domain-containing protein.	Scavenger mRNA decapping enzyme c-term binding domain-containing protein.	0.999
AG1IA_01558	AG1IA_01379	L8X5P3	L8X658	Translin domain-containing protein.	Nuclear cap-binding protein subunit 2.	0.675
AG1IA_01558	AG1IA_04679	L8X5P3	L8WT70	Translin domain-containing protein.	Argonaute-like protein; Belongs to the argonaute family.	0.738
AG1IA_01558	AG1IA_05661	L8X5P3	L8WQP9	Translin domain-containing protein.	Serine/threonine kinase receptor associated protein.	0.613
AG1IA_01558	AG1IA_06462	L8X5P3	L8WRZ3	Translin domain-containing protein.	ArgoN domain-containing protein.	0.726
AG1IA_01558	AG1IA_06467	L8X5P3	L8WRY9	Translin domain-containing protein.	Piwi domain-containing protein.	0.738
AG1IA_01558	AG1IA_06973	L8X5P3	L8WRJ5	Translin domain-containing protein.	DUF605 domain-containing protein.	0.555
AG1IA_01558	AG1IA_08233	L8X5P3	L8WLP4	Translin domain-containing protein.	Argonaute-like protein.	0.738

page 1 of 2

Network Stats

number of nodes:

10

number of edges:

16

average node degree:

3.2

avg. local clustering coefficient:

0.919

expected number of edges:

9

PPI enrichment p-value:

0.0286

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042147

Retrograde transport, endosome to Golgi

4 of 87

1.96

1.48

0.0014

GO:0072673

Lamellipodium morphogenesis

2 of 7

2.75

0.85

0.0326

GO:0034498

Early endosome to Golgi transport

2 of 9

2.64

0.8

0.0399

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005158

Insulin receptor binding

3 of 23

2.41

1.62

0.0012

GO:1990460

Leptin receptor binding

2 of 4

2.99

1.18

0.0086

GO:1990459

Transferrin receptor binding

2 of 11

2.55

0.94

0.0222

GO:0034452

Dynactin binding

2 of 12

2.52

0.94

0.0222

GO:0035091

Phosphatidylinositol binding

4 of 270

1.47

0.9

0.0118

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030905

Retromer, tubulation complex

4 of 4

3.29

4.72

4.78e-09

GO:0097422

Tubular endosome

2 of 5

2.9

1.48

0.0025

GO:0031901

Early endosome membrane

4 of 180

1.64

1.4

0.0010

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:11485546

(2001) A large family of endosome-localized proteins related to sorting nexin 1.

4 of 6

3.12

2.53

3.54e-05

PMID:24866125

(2014) Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.

4 of 9

2.94

2.49

4.01e-05

PMID:24735875

(2014) Going forward with retromer.

4 of 9

2.94

2.49

4.01e-05

PMID:18472259

(2008) Retromer.

4 of 9

2.94

2.49

4.01e-05

PMID:31576058

(2019) Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins.

5 of 38

2.41

2.42

3.54e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14014

Retromer, tubulation complex

4 of 5

3.2

4.37

1.92e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hsa04144

Endocytosis

4 of 241

1.51

1.24

0.0016

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030905

Retromer, tubulation complex

4 of 4

3.29

4.69

5.38e-09

GOCC:0097422

Tubular endosome

2 of 5

2.9

1.39

0.0037

GOCC:0010008

Endosome membrane

4 of 330

1.38

0.91

0.0090

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0446

Lipid-binding

4 of 251

1.5

1.11

0.0036

KW-0967

Endosome

4 of 568

1.14

0.59

0.0431

KW-0653

Protein transport

4 of 617

1.11

0.57

0.0431

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09325

Vps5 C terminal like

4 of 5

3.2

4.53

9.72e-09

PF03700

Sorting nexin, N-terminal domain

2 of 2

3.29

1.6

0.0016

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015404

Sorting nexin/Vps5-like, C-terminal

4 of 5

3.2

4.26

3.02e-08

IPR001683

Phox homology

4 of 46

2.23

2.41

2.73e-05

IPR036871

PX domain superfamily

4 of 51

2.19

2.38

2.73e-05

IPR027267

AH/BAR domain superfamily

4 of 77

2.01

2.03

9.80e-05

IPR005329

Sorting nexin, N-terminal

2 of 2

3.29

1.55

0.0020

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00312

PhoX homologous domain, present in p47phox and p40phox.

3 of 42

2.15

1.59

0.0011

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