TNIP1 protein (Camelus dromedarius) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

Your Input:

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[Homology]

Score

TNIP1

TNFAIP3-interacting protein 1. (663 aa)

Predicted Functional Partners:

TNFAIP3

0.986

TNF

0.945

TNFRSF1A

0.936

UBB

0.733

STAMBPL1

0.615

NFKB1

0.562

NFKB2

0.510

SLC39A7

0.506

OTUD7B

0.496

CFAP97

0.489

Your Current Organism:

Camelus dromedarius

NCBI taxonomy Id: 9838
Other names: Arabian camel, C. dromedarius, camel, dromedaries, dromedary, dromedary camel, one-humped camel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFAP97	TNIP1	ENSCDRP00005021337	ENSCDRP00005002661	Cilia-and flagella-associated protein 97.	TNFAIP3-interacting protein 1.	0.489
NFKB1	NFKB2	ENSCDRP00005024284	ENSCDRP00005020270	Nuclear factor NF-kappa-B p105 subunit.	Nuclear factor NF-kappa-B p100 subunit.	0.995
NFKB1	TNF	ENSCDRP00005024284	ENSCDRP00005029471	Nuclear factor NF-kappa-B p105 subunit.	Tumor necrosis factor.	0.934
NFKB1	TNFAIP3	ENSCDRP00005024284	ENSCDRP00005021006	Nuclear factor NF-kappa-B p105 subunit.	Tumor necrosis factor alpha-induced protein 3.	0.465
NFKB1	TNIP1	ENSCDRP00005024284	ENSCDRP00005002661	Nuclear factor NF-kappa-B p105 subunit.	TNFAIP3-interacting protein 1.	0.562
NFKB1	UBB	ENSCDRP00005024284	ENSCDRP00005020992	Nuclear factor NF-kappa-B p105 subunit.	Polyubiquitin-B.	0.591
NFKB2	NFKB1	ENSCDRP00005020270	ENSCDRP00005024284	Nuclear factor NF-kappa-B p100 subunit.	Nuclear factor NF-kappa-B p105 subunit.	0.995
NFKB2	TNFAIP3	ENSCDRP00005020270	ENSCDRP00005021006	Nuclear factor NF-kappa-B p100 subunit.	Tumor necrosis factor alpha-induced protein 3.	0.627
NFKB2	TNIP1	ENSCDRP00005020270	ENSCDRP00005002661	Nuclear factor NF-kappa-B p100 subunit.	TNFAIP3-interacting protein 1.	0.510
NFKB2	UBB	ENSCDRP00005020270	ENSCDRP00005020992	Nuclear factor NF-kappa-B p100 subunit.	Polyubiquitin-B.	0.475
OTUD7B	TNF	ENSCDRP00005023069	ENSCDRP00005029471	OTU domain-containing protein 7B.	Tumor necrosis factor.	0.564
OTUD7B	TNFRSF1A	ENSCDRP00005023069	ENSCDRP00005015378	OTU domain-containing protein 7B.	Tumor necrosis factor receptor superfamily member 1A.	0.417
OTUD7B	TNIP1	ENSCDRP00005023069	ENSCDRP00005002661	OTU domain-containing protein 7B.	TNFAIP3-interacting protein 1.	0.496
OTUD7B	UBB	ENSCDRP00005023069	ENSCDRP00005020992	OTU domain-containing protein 7B.	Polyubiquitin-B.	0.699
SLC39A7	TNIP1	ENSCDRP00005031737	ENSCDRP00005002661	Zinc transporter SLC39A7.	TNFAIP3-interacting protein 1.	0.506
STAMBPL1	TNIP1	ENSCDRP00005009839	ENSCDRP00005002661	AMSH-like protease.	TNFAIP3-interacting protein 1.	0.615
STAMBPL1	UBB	ENSCDRP00005009839	ENSCDRP00005020992	AMSH-like protease.	Polyubiquitin-B.	0.847
TNF	NFKB1	ENSCDRP00005029471	ENSCDRP00005024284	Tumor necrosis factor.	Nuclear factor NF-kappa-B p105 subunit.	0.934
TNF	OTUD7B	ENSCDRP00005029471	ENSCDRP00005023069	Tumor necrosis factor.	OTU domain-containing protein 7B.	0.564
TNF	TNFAIP3	ENSCDRP00005029471	ENSCDRP00005021006	Tumor necrosis factor.	Tumor necrosis factor alpha-induced protein 3.	0.975

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.528

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031419

Cobalamin binding

5 of 13

2.03

2.83

9.75e-07

GO:0016866

Intramolecular transferase activity

5 of 19

1.86

2.51

2.40e-06

GO:0046872

Metal ion binding

7 of 491

0.6

0.36

0.0419

GO:0036094

Small molecule binding

7 of 512

0.58

0.35

0.0424

GO:0043167

Ion binding

9 of 859

0.46

0.31

0.0327

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2194

Cobalamin binding, and Glyoxalase-like domain

7 of 12

2.21

4.9

2.12e-11

CL:2196

Mixed, incl. Methylmalonyl-CoA mutase, and Glyoxalase-like domain

3 of 6

2.14

1.66

0.00062

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00280

Valine, leucine and isoleucine degradation

8 of 33

1.83

4.01

8.96e-12

map00640

Propanoate metabolism

7 of 36

1.73

3.24

1.14e-09

map00630

Glyoxylate and dicarboxylate metabolism

7 of 54

1.56

2.58

1.01e-08

map01200

Carbon metabolism

7 of 147

1.12

1.28

5.53e-06

map01120

Microbial metabolism in diverse environments

7 of 399

0.69

0.52

0.0031

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02310

B12 binding domain

4 of 8

2.14

2.36

2.00e-05

PF13468

Glyoxalase-like domain

2 of 3

2.27

0.85

0.0267

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036724

Cobalamin-binding domain superfamily

4 of 7

2.2

2.27

3.61e-05

IPR006158

Cobalamin (vitamin B12)-binding domain

4 of 7

2.2

2.27

3.61e-05

IPR006159

Methylmalonyl-CoA mutase, C-terminal

3 of 3

2.44

1.9

0.00028

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