STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGRA_1131Short chain dehydrogenase; COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases). (273 aa)    
Predicted Functional Partners:
ppiB
COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family.
  
 
 0.595
fadJ
3-hydroxyacyl-CoA dehydrogenase; COG1024 Enoyl-CoA hydratase/carnithine racemase.
 
 0.568
SGRA_1132
Two component, sigma54 specific, Fis family transcriptional regulator; COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain.
     
 0.545
SGRA_1002
COG2124 Cytochrome P450.
   
 0.526
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 
 0.523
fabD
COG0331 (acyl-carrier-protein) S-malonyltransferase.
  
 
 0.509
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.488
lpxC
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily.
  
 
 0.485
SGRA_1401
Beta-ketoacyl synthase; COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 
 0.446
fabF
3-oxoacyl-(acyl-carrier-protein) synthase ii; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
  
 
 0.446
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.