STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGRA_2500Sigma54 specific transcriptional regulator, Fis family protein; COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains. (433 aa)    
Predicted Functional Partners:
rpoN
COG1508 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog.
 
  
 0.809
SGRA_2499
Hypothetical protein.
       0.732
cheA
COG0643 Chemotaxis protein histidine kinase and related kinases.
  
 
 0.715
mcp
Methyl-accepting chemotaxis protein; COG2202 FOG: PAS/PAC domain.
  
 
 0.571
pleC1
Two-component hybrid sensor and regulator; COG0642 Signal transduction histidine kinase.
  
 
 0.551
miaB
(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
       0.512
degS
Multi-sensor signal transduction histidine kinase; COG2202 FOG: PAS/PAC domain.
   
 
 0.491
cheB
Protein-glutamate methylesterase, two-component response regulator, chemotaxis; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
  
  
 0.427
cheR
MCP methyltransferase, CheR-type; COG1352 Methylase of chemotaxis methyl-accepting proteins.
  
  
 0.420
SGRA_3227
MCP methyltransferase, CheR-type; COG1352 Methylase of chemotaxis methyl-accepting proteins.
  
  
 0.420
Your Current Organism:
Saprospira grandis
NCBI taxonomy Id: 984262
Other names: S. grandis str. Lewin, Saprospira grandis str. Lewin, Saprospira grandis strain Lewin
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