STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDW13978.1L-threonine synthase. (462 aa)    
Predicted Functional Partners:
SDW22912.1
Homoserine dehydrogenase.
 
 0.953
SDX45076.1
Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
  
 0.946
ilvA
L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.945
SDX45879.1
Threonine dehydratase.
  
 
 0.945
SDX18543.1
Homoserine dehydrogenase.
 
 0.943
SDW14757.1
Aspartate kinase; Belongs to the aspartokinase family.
  
 
 0.936
SDW71432.1
L-threonine aldolase.
  
 0.924
SDW68203.1
Threonine dehydratase.
  
 
 0.911
pdxA
4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
    
  0.872
SDW75158.1
L-threonine ammonia-lyase.
  
 
 0.865
Your Current Organism:
Ruegeria halocynthiae
NCBI taxonomy Id: 985054
Other names: CCUG 60744, DSM 27839, KCTC 23463, R. halocynthiae, Ruegeria halocynthiae Kim et al. 2012, Ruegeria sp. MA1-6, strain MA1-6
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