STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
gptPutative phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (167 aa)    
Predicted Functional Partners:
guaB
Inosine-5''-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.944
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 0.916
guaA
GMP synthase, C-terminal domain protein or B subunit/GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.914
AKO96561.1
Inosine-uridine nucleoside N-ribohydrolase.
    
 0.909
AKO98720.1
Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
 
  0.904
AKO96562.1
MazG family protein.
     
 0.902
deoD
Purine-nucleoside phosphorylase, family 1 (deoD).
    
  0.902
AKO96052.1
GMP synthase - Glutamine amidotransferase domain protein.
    
  0.901
AKO96046.1
Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
     
  0.900
AKO96310.1
Xanthine dehydrogenase, small subunit.
     
  0.900
Your Current Organism:
Marinovum algicola
NCBI taxonomy Id: 988812
Other names: M. algicola DG 898, Marinovum algicola DG 898, Marinovum algicola str. DG 898, Marinovum algicola strain DG 898
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