node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKO96302.1 | AKO96995.1 | MALG_01114 | MALG_01823 | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | DNA or RNA helicase of superfamily II. | 0.537 |
AKO96302.1 | AKO98703.1 | MALG_01114 | MALG_03560 | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | Disulfide bond chaperones of the HSP33 family; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. | 0.852 |
AKO96302.1 | dnaJ | MALG_01114 | MALG_03177 | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.576 |
AKO96302.1 | grpE | MALG_01114 | MALG_03574 | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.568 |
AKO96302.1 | hslU | MALG_01114 | MALG_03516 | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | ATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.594 |
AKO96302.1 | hslV | MALG_01114 | MALG_03514 | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | ATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.698 |
AKO96995.1 | AKO96302.1 | MALG_01823 | MALG_01114 | DNA or RNA helicase of superfamily II. | Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit; S4-like protein. | 0.537 |
AKO96995.1 | AKO98703.1 | MALG_01823 | MALG_03560 | DNA or RNA helicase of superfamily II. | Disulfide bond chaperones of the HSP33 family; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. | 0.594 |
AKO96995.1 | dnaJ | MALG_01823 | MALG_03177 | DNA or RNA helicase of superfamily II. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.986 |
AKO96995.1 | grpE | MALG_01823 | MALG_03574 | DNA or RNA helicase of superfamily II. | Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...] | 0.863 |
AKO96995.1 | hslU | MALG_01823 | MALG_03516 | DNA or RNA helicase of superfamily II. | ATP-dependent protease HslVU, ATPase subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.863 |
AKO96995.1 | hslV | MALG_01823 | MALG_03514 | DNA or RNA helicase of superfamily II. | ATP-dependent protease HslVU, peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.870 |
AKO98697.1 | AKO98701.1 | MALG_03554 | MALG_03558 | Related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.732 |
AKO98697.1 | AKO98702.1 | MALG_03554 | MALG_03559 | Related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | NTP pyrophosphohydrolase; Including oxidative damage repair enzymes. | 0.680 |
AKO98697.1 | AKO98703.1 | MALG_03554 | MALG_03560 | Related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | Disulfide bond chaperones of the HSP33 family; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. | 0.762 |
AKO98697.1 | AKO98704.1 | MALG_03554 | MALG_03561 | Related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | 0.460 |
AKO98701.1 | AKO98697.1 | MALG_03558 | MALG_03554 | tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Related to tRNA (uracil-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 0.732 |
AKO98701.1 | AKO98702.1 | MALG_03558 | MALG_03559 | tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | NTP pyrophosphohydrolase; Including oxidative damage repair enzymes. | 0.887 |
AKO98701.1 | AKO98703.1 | MALG_03558 | MALG_03560 | tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Disulfide bond chaperones of the HSP33 family; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress; Belongs to the HSP33 family. | 0.868 |
AKO98701.1 | AKO98704.1 | MALG_03558 | MALG_03561 | tRNA nucleotidyltransferase/poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | ADP-ribose pyrophosphatase; Belongs to the Nudix hydrolase family. | 0.721 |