STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mcrAMethyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis. (559 aa)    
Predicted Functional Partners:
mcrG
Methyl-coenzyme M reductase, gamma subunit; Protein involved in coenzyme-B sulfoethylthiotransferase activity.
  
 0.999
mcrB
Methyl-coenzyme M reductase, beta subunit.
  
 0.999
mcrD
Methyl-coenzyme M reductase operon protein D.
  
 
 0.997
mcrC
Methyl-coenzyme M reductase operon protein C.
  
 
 0.989
mtrA
Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
  
 
 0.965
atwA
Methyl coenzyme M reductase system, component A2.
    
 0.916
MCON_2841
ABC transporter, ATP-binding protein.
    
 0.911
hdrE
CoB--CoM heterodisulfide reductase subunit E.
     
 0.909
hdrD-2
CoB--CoM heterodisulfide reductase iron-sulfur subunit D.
    
 0.903
mtd
F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
      
 0.883
Your Current Organism:
Methanothrix soehngenii
NCBI taxonomy Id: 990316
Other names: M. soehngenii GP6, Methanosaeta concilii DSM 3671, Methanosaeta concilii GP6, Methanothrix soehngenii DSM 3671, Methanothrix soehngenii GP6
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