MCON_1701 protein (Methanothrix soehngenii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MCON_1701

Transmembrane protein (UPF0016). (199 aa)

Predicted Functional Partners:

infB

0.641

rpl24e

0.479

ndk

0.445

rps28e

0.437

rpl7ae

0.409

Your Current Organism:

Methanothrix soehngenii

NCBI taxonomy Id: 990316
Other names: M. soehngenii GP6, Methanosaeta concilii DSM 3671, Methanosaeta concilii GP6, Methanothrix soehngenii DSM 3671, Methanothrix soehngenii GP6

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCON_1701	infB	MCON_1701	MCON_1702	Transmembrane protein (UPF0016).	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.641
MCON_1701	ndk	MCON_1701	MCON_1703	Transmembrane protein (UPF0016).	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.445
MCON_1701	rpl24e	MCON_1701	MCON_1704	Transmembrane protein (UPF0016).	Ribosomal protein L24e; Binds to the 23S rRNA.	0.479
MCON_1701	rpl7ae	MCON_1701	MCON_1706	Transmembrane protein (UPF0016).	Ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.409
MCON_1701	rps28e	MCON_1701	MCON_1705	Transmembrane protein (UPF0016).	Ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.	0.437
infB	MCON_1701	MCON_1702	MCON_1701	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	Transmembrane protein (UPF0016).	0.641
infB	ndk	MCON_1702	MCON_1703	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.900
infB	rpl24e	MCON_1702	MCON_1704	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	Ribosomal protein L24e; Binds to the 23S rRNA.	0.947
infB	rpl7ae	MCON_1702	MCON_1706	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	Ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.997
infB	rps28e	MCON_1702	MCON_1705	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	Ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.	0.971
ndk	MCON_1701	MCON_1703	MCON_1701	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Transmembrane protein (UPF0016).	0.445
ndk	infB	MCON_1703	MCON_1702	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.900
ndk	rpl24e	MCON_1703	MCON_1704	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Ribosomal protein L24e; Binds to the 23S rRNA.	0.886
ndk	rpl7ae	MCON_1703	MCON_1706	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.819
ndk	rps28e	MCON_1703	MCON_1705	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	Ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.	0.942
rpl24e	MCON_1701	MCON_1704	MCON_1701	Ribosomal protein L24e; Binds to the 23S rRNA.	Transmembrane protein (UPF0016).	0.479
rpl24e	infB	MCON_1704	MCON_1702	Ribosomal protein L24e; Binds to the 23S rRNA.	Translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.947
rpl24e	ndk	MCON_1704	MCON_1703	Ribosomal protein L24e; Binds to the 23S rRNA.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.	0.886
rpl24e	rpl7ae	MCON_1704	MCON_1706	Ribosomal protein L24e; Binds to the 23S rRNA.	Ribosomal protein L7Ae; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.	0.999
rpl24e	rps28e	MCON_1704	MCON_1705	Ribosomal protein L24e; Binds to the 23S rRNA.	Ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family.	0.999

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.923

expected number of edges:

14

PPI enrichment p-value:

6.66e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016558

Protein import into peroxisome matrix

9 of 13

2.88

10.37

6.14e-21

GO:0016560

Protein import into peroxisome matrix, docking

5 of 6

2.96

5.77

1.86e-11

GO:0006886

Intracellular protein transport

10 of 275

1.6

3.49

1.39e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005052

Peroxisome matrix targeting signal-1 binding

2 of 2

3.04

1.2

0.0069

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005778

Peroxisomal membrane

8 of 33

2.42

7.05

1.09e-15

GO:0005777

Peroxisome

9 of 87

2.05

5.81

1.22e-15

GO:1990429

Peroxisomal importomer complex

4 of 4

3.04

4.57

4.03e-09

GO:0016020

Membrane

9 of 2199

0.65

0.53

0.00075

GO:0005829

Cytosol

5 of 821

0.82

0.49

0.0288

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9523

Protein import into peroxisome matrix, and Pex19 protein

9 of 15

2.82

10.18

8.65e-21

CL:9540

Peroxisomal importomer complex, and Pex19 protein

3 of 5

2.82

2.74

9.38e-06

CL:9525

Protein import into peroxisome matrix, and Bile acid metabolic process

3 of 6

2.74

2.67

1.21e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04146

Peroxisome

9 of 92

2.03

5.73

1.11e-15

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9033241

Peroxisomal protein import

9 of 139

1.85

4.44

2.49e-13

MAP-9609507

Protein localization

9 of 216

1.66

3.47

5.83e-12

MAP-9603798

Class I peroxisomal membrane protein import

4 of 22

2.3

2.94

1.73e-06

MAP-9664873

Pexophagy

2 of 9

2.39

1.09

0.0097

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005778

Peroxisomal membrane

7 of 27

2.45

6.16

2.28e-13

GOCC:0005777

Peroxisome

8 of 94

1.97

4.71

1.01e-12

GOCC:0016020

Membrane

8 of 1387

0.8

0.68

0.00051

GOCC:0005737

Cytoplasm

9 of 2852

0.54

0.39

0.0096

GOCC:0005622

Intracellular

11 of 5889

0.31

0.24

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04757

Pex2 / Pex12 amino terminal region

2 of 2

3.04

1.28

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025655

Peroxisomal membrane protein 14

2 of 2

3.04

1.03

0.0139

IPR024111

PEX5/PEX5L

2 of 2

3.04

1.03

0.0139

IPR006845

Pex, N-terminal

2 of 2

3.04

1.03

0.0139

IPR006785

Peroxisome membrane anchor protein Pex14p, N-terminal

2 of 2

3.04

1.03

0.0139

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About