STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hdrCCoB-CoM heterodisulfide reductase subunit C. (176 aa)    
Predicted Functional Partners:
hdrA
CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
 0.999
hdrB
CoB-CoM heterodisulfide reductase, subunit B.
 
 0.999
hdrD-2
CoB--CoM heterodisulfide reductase iron-sulfur subunit D.
 
 0.992
hdrE
CoB--CoM heterodisulfide reductase subunit E.
     
 0.984
fdhA
Formate dehydrogenase, alpha subunit; Protein involved in formate dehydrogenase activity, formate dehydrogenase complex and formate metabolic process.
  
 0.950
hdrD
CoB--CoM heterodisulfide reductase iron-sulfur subunit D.
 
 
 0.933
mcrA
Methyl-coenzyme M reductase, alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
    
 0.708
mtrE
Tetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
  
 
 0.696
mtrA
Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
    
 0.691
MCON_2872
Tetrahydromethanopterin S-methyltransferase, subunit A, putative.
    
 0.691
Your Current Organism:
Methanothrix soehngenii
NCBI taxonomy Id: 990316
Other names: M. soehngenii GP6, Methanosaeta concilii DSM 3671, Methanosaeta concilii GP6, Methanothrix soehngenii DSM 3671, Methanothrix soehngenii GP6
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.