node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUL1 | FBXO4 | ENSBTAP00000063991 | ENSBTAP00000022583 | Cullin 1; Belongs to the cullin family. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.881 |
CUL1 | FBXW2 | ENSBTAP00000063991 | ENSBTAP00000067173 | Cullin 1; Belongs to the cullin family. | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.854 |
CUL1 | FBXW4 | ENSBTAP00000063991 | ENSBTAP00000004657 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 4. | 0.744 |
CUL1 | FBXW5 | ENSBTAP00000063991 | ENSBTAP00000072648 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 5. | 0.864 |
CUL1 | FBXW8 | ENSBTAP00000063991 | ENSBTAP00000047345 | Cullin 1; Belongs to the cullin family. | F-box and WD repeat domain containing 8. | 0.891 |
CUL1 | LOC780968 | ENSBTAP00000063991 | ENSBTAP00000061525 | Cullin 1; Belongs to the cullin family. | RING-type domain-containing protein. | 0.996 |
CUL1 | NAE1 | ENSBTAP00000063991 | ENSBTAP00000013367 | Cullin 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.887 |
CUL1 | SKP1 | ENSBTAP00000063991 | ENSBTAP00000035184 | Cullin 1; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
FBXO4 | CUL1 | ENSBTAP00000022583 | ENSBTAP00000063991 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | Cullin 1; Belongs to the cullin family. | 0.881 |
FBXO4 | FBXW2 | ENSBTAP00000022583 | ENSBTAP00000067173 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.709 |
FBXO4 | FBXW4 | ENSBTAP00000022583 | ENSBTAP00000004657 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | F-box and WD repeat domain containing 4. | 0.684 |
FBXO4 | FBXW5 | ENSBTAP00000022583 | ENSBTAP00000072648 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | F-box and WD repeat domain containing 5. | 0.689 |
FBXO4 | FBXW8 | ENSBTAP00000022583 | ENSBTAP00000047345 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | F-box and WD repeat domain containing 8. | 0.807 |
FBXO4 | LOC780968 | ENSBTAP00000022583 | ENSBTAP00000061525 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | RING-type domain-containing protein. | 0.471 |
FBXO4 | NAE1 | ENSBTAP00000022583 | ENSBTAP00000013367 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.508 |
FBXO4 | SKP1 | ENSBTAP00000022583 | ENSBTAP00000035184 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.891 |
FBXW2 | CUL1 | ENSBTAP00000067173 | ENSBTAP00000063991 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Cullin 1; Belongs to the cullin family. | 0.854 |
FBXW2 | FBXO4 | ENSBTAP00000067173 | ENSBTAP00000022583 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity). | 0.709 |
FBXW2 | FBXW4 | ENSBTAP00000067173 | ENSBTAP00000004657 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box and WD repeat domain containing 4. | 0.701 |
FBXW2 | FBXW5 | ENSBTAP00000067173 | ENSBTAP00000072648 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box and WD repeat domain containing 5. | 0.688 |