node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F2 | F2RL2 | ENSBTAP00000009406 | ENSBTAP00000001191 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | 0.989 |
F2 | F2RL3 | ENSBTAP00000009406 | ENSBTAP00000012283 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.983 |
F2 | KNG1 | ENSBTAP00000009406 | ENSBTAP00000048995 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Kininogen-1 heavy chain; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of [...] | 0.868 |
F2 | PLG | ENSBTAP00000009406 | ENSBTAP00000001674 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.903 |
F2RL2 | F2 | ENSBTAP00000001191 | ENSBTAP00000009406 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.989 |
F2RL2 | F2RL3 | ENSBTAP00000001191 | ENSBTAP00000012283 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.910 |
F2RL2 | GZMA | ENSBTAP00000001191 | ENSBTAP00000029273 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | GZMA protein; Belongs to the peptidase S1 family. | 0.681 |
F2RL2 | KNG1 | ENSBTAP00000001191 | ENSBTAP00000048995 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Kininogen-1 heavy chain; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of [...] | 0.631 |
F2RL2 | LOC505658 | ENSBTAP00000001191 | ENSBTAP00000052108 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.681 |
F2RL2 | LOC780933 | ENSBTAP00000001191 | ENSBTAP00000004737 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Alpha-trypsin chain 1. | 0.681 |
F2RL2 | PLG | ENSBTAP00000001191 | ENSBTAP00000001674 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.681 |
F2RL2 | PRSS2 | ENSBTAP00000001191 | ENSBTAP00000028731 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Anionic trypsin; Belongs to the peptidase S1 family. | 0.681 |
F2RL2 | SDR42E2 | ENSBTAP00000001191 | ENSBTAP00000017350 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Short chain dehydrogenase/reductase family 42E, member 2. | 0.580 |
F2RL2 | gzmA | ENSBTAP00000001191 | ENSBTAP00000039959 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity); Belongs to the peptidase S1 [...] | 0.681 |
F2RL3 | F2 | ENSBTAP00000012283 | ENSBTAP00000009406 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.983 |
F2RL3 | F2RL2 | ENSBTAP00000012283 | ENSBTAP00000001191 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; Belongs to the G-protein coupled receptor 1 family. | 0.910 |
F2RL3 | GZMA | ENSBTAP00000012283 | ENSBTAP00000029273 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | GZMA protein; Belongs to the peptidase S1 family. | 0.690 |
F2RL3 | KNG1 | ENSBTAP00000012283 | ENSBTAP00000048995 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Kininogen-1 heavy chain; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of [...] | 0.509 |
F2RL3 | LOC505658 | ENSBTAP00000012283 | ENSBTAP00000052108 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.726 |
F2RL3 | LOC780933 | ENSBTAP00000012283 | ENSBTAP00000004737 | F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. | Alpha-trypsin chain 1. | 0.681 |