node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RMND5B | UBE2H | ENSBTAP00000008362 | ENSBTAP00000001205 | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. | 0.784 |
RMND5B | YPEL5 | ENSBTAP00000008362 | ENSBTAP00000032456 | Required for meiotic nuclear division 5 homolog B (S. cerevisiae). | Protein yippee-like 5; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity). | 0.904 |
UBA1 | UBA3 | ENSBTAP00000057326 | ENSBTAP00000071509 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin like modifier activating enzyme 3. | 0.844 |
UBA1 | UBA6 | ENSBTAP00000057326 | ENSBTAP00000008985 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin like modifier activating enzyme 6. | 0.944 |
UBA1 | UBA7 | ENSBTAP00000057326 | ENSBTAP00000016365 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin like modifier activating enzyme 7. | 0.906 |
UBA1 | UBE2H | ENSBTAP00000057326 | ENSBTAP00000001205 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. | 0.833 |
UBA1 | UBE2J1 | ENSBTAP00000057326 | ENSBTAP00000024529 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin conjugating enzyme E2 J1. | 0.644 |
UBA1 | UBE2J2 | ENSBTAP00000057326 | ENSBTAP00000069660 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. | 0.708 |
UBA1 | UBE2O | ENSBTAP00000057326 | ENSBTAP00000026793 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin conjugating enzyme E2 O. | 0.847 |
UBA1 | UBE2Z | ENSBTAP00000057326 | ENSBTAP00000040996 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | Ubiquitin conjugating enzyme E2 Z. | 0.828 |
UBA3 | UBA1 | ENSBTAP00000071509 | ENSBTAP00000057326 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | 0.844 |
UBA3 | UBA6 | ENSBTAP00000071509 | ENSBTAP00000008985 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin like modifier activating enzyme 6. | 0.720 |
UBA3 | UBA7 | ENSBTAP00000071509 | ENSBTAP00000016365 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin like modifier activating enzyme 7. | 0.641 |
UBA3 | UBE2H | ENSBTAP00000071509 | ENSBTAP00000001205 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. | 0.795 |
UBA3 | UBE2J1 | ENSBTAP00000071509 | ENSBTAP00000024529 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin conjugating enzyme E2 J1. | 0.640 |
UBA3 | UBE2J2 | ENSBTAP00000071509 | ENSBTAP00000069660 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family. | 0.634 |
UBA3 | UBE2O | ENSBTAP00000071509 | ENSBTAP00000026793 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin conjugating enzyme E2 O. | 0.602 |
UBA3 | UBE2Z | ENSBTAP00000071509 | ENSBTAP00000040996 | Ubiquitin like modifier activating enzyme 3. | Ubiquitin conjugating enzyme E2 Z. | 0.762 |
UBA6 | UBA1 | ENSBTAP00000008985 | ENSBTAP00000057326 | Ubiquitin like modifier activating enzyme 6. | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. | 0.944 |
UBA6 | UBA3 | ENSBTAP00000008985 | ENSBTAP00000071509 | Ubiquitin like modifier activating enzyme 6. | Ubiquitin like modifier activating enzyme 3. | 0.720 |