node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP10 | AKAP3 | ENSBTAP00000041402 | ENSBTAP00000001353 | A-kinase anchoring protein 10. | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | 0.690 |
AKAP10 | PRKACA | ENSBTAP00000041402 | ENSBTAP00000063436 | A-kinase anchoring protein 10. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.755 |
AKAP3 | AKAP10 | ENSBTAP00000001353 | ENSBTAP00000041402 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | A-kinase anchoring protein 10. | 0.690 |
AKAP3 | CABYR | ENSBTAP00000001353 | ENSBTAP00000031584 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Calcium binding tyrosine-(Y)-phosphorylation regulated. | 0.873 |
AKAP3 | FSIP2 | ENSBTAP00000001353 | ENSBTAP00000045033 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Fibrous sheath interacting protein 2. | 0.676 |
AKAP3 | ODF1 | ENSBTAP00000001353 | ENSBTAP00000004476 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.813 |
AKAP3 | PDE4A | ENSBTAP00000001353 | ENSBTAP00000015961 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Phosphodiesterase. | 0.696 |
AKAP3 | PRKACA | ENSBTAP00000001353 | ENSBTAP00000063436 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.695 |
AKAP3 | PRM1 | ENSBTAP00000001353 | ENSBTAP00000043964 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Sperm protamine P1. | 0.674 |
AKAP3 | ROPN1 | ENSBTAP00000001353 | ENSBTAP00000009113 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.821 |
AKAP3 | ROPN1L | ENSBTAP00000001353 | ENSBTAP00000069146 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.678 |
AKAP3 | SPA17 | ENSBTAP00000001353 | ENSBTAP00000044793 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. | 0.763 |
CABYR | AKAP3 | ENSBTAP00000031584 | ENSBTAP00000001353 | Calcium binding tyrosine-(Y)-phosphorylation regulated. | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | 0.873 |
CABYR | FSIP2 | ENSBTAP00000031584 | ENSBTAP00000045033 | Calcium binding tyrosine-(Y)-phosphorylation regulated. | Fibrous sheath interacting protein 2. | 0.657 |
CABYR | ODF1 | ENSBTAP00000031584 | ENSBTAP00000004476 | Calcium binding tyrosine-(Y)-phosphorylation regulated. | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. | 0.724 |
CABYR | ROPN1 | ENSBTAP00000031584 | ENSBTAP00000009113 | Calcium binding tyrosine-(Y)-phosphorylation regulated. | Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.783 |
CABYR | ROPN1L | ENSBTAP00000031584 | ENSBTAP00000069146 | Calcium binding tyrosine-(Y)-phosphorylation regulated. | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. Belongs to the ropporin family. | 0.668 |
CABYR | SPA17 | ENSBTAP00000031584 | ENSBTAP00000044793 | Calcium binding tyrosine-(Y)-phosphorylation regulated. | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates. | 0.797 |
FSIP2 | AKAP3 | ENSBTAP00000045033 | ENSBTAP00000001353 | Fibrous sheath interacting protein 2. | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. | 0.676 |
FSIP2 | CABYR | ENSBTAP00000045033 | ENSBTAP00000031584 | Fibrous sheath interacting protein 2. | Calcium binding tyrosine-(Y)-phosphorylation regulated. | 0.657 |