STRINGSTRING
PRKCA protein (Bos taurus) - STRING interaction network
"PRKCA" - Protein kinase C alpha type in Bos taurus
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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PRKCAProtein kinase C alpha type ; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (576 aa)    
Predicted Functional Partners:
RHOA
Transforming protein RhoA ; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and [...] (193 aa)
     
  0.977
BRAF
Uncharacterized protein (781 aa)
     
0.960
PDPK1
Uncharacterized protein (557 aa)
     
0.958
MTOR
Uncharacterized protein (2551 aa)
     
  0.958
MAPK3
Mitogen-activated protein kinase 3 (362 aa)
       
0.948
MAPK1
Mitogen-activated protein kinase 1 ; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays [...] (320 aa)
     
0.947
PLD1
Phospholipase D1 (1034 aa)
     
  0.939
PLD2
Phospholipase D2 ; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (904 aa)
     
  0.939
HRAS
GTPase HRas isoform 1 (246 aa)
     
  0.929
KRAS
GTPase KRas (188 aa)
     
  0.929
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae, Bovidae sp. Adi Nefas, Bovinae, Pecora, Ruminantia, bovine, cattle, cow, domestic cattle, domestic cow, oxen, cattle
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