node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CP | FECH | ENSBTAP00000016137 | ENSBTAP00000008384 | Ceruloplasmin; Belongs to the multicopper oxidase family. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.924 |
CP | FXN | ENSBTAP00000016137 | ENSBTAP00000001725 | Ceruloplasmin; Belongs to the multicopper oxidase family. | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | 0.919 |
CP | HEPH | ENSBTAP00000016137 | ENSBTAP00000054213 | Ceruloplasmin; Belongs to the multicopper oxidase family. | Hephaestin; Belongs to the multicopper oxidase family. | 0.903 |
CP | HMOX1 | ENSBTAP00000016137 | ENSBTAP00000061215 | Ceruloplasmin; Belongs to the multicopper oxidase family. | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | 0.929 |
CP | HMOX2 | ENSBTAP00000016137 | ENSBTAP00000044292 | Ceruloplasmin; Belongs to the multicopper oxidase family. | Heme oxygenase 2. | 0.912 |
FDX2 | FECH | ENSBTAP00000013630 | ENSBTAP00000008384 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.551 |
FDX2 | FXN | ENSBTAP00000013630 | ENSBTAP00000001725 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | 0.894 |
FDX2 | HMOX1 | ENSBTAP00000013630 | ENSBTAP00000061215 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | 0.420 |
FDX2 | HMOX2 | ENSBTAP00000013630 | ENSBTAP00000044292 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Heme oxygenase 2. | 0.491 |
FDX2 | ISCU | ENSBTAP00000013630 | ENSBTAP00000015648 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.965 |
FDX2 | LYRM4 | ENSBTAP00000013630 | ENSBTAP00000042040 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | 0.965 |
FDX2 | NFS1 | ENSBTAP00000013630 | ENSBTAP00000009149 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | NFS1 protein. | 0.963 |
FDX2 | SCLY | ENSBTAP00000013630 | ENSBTAP00000013719 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. | 0.651 |
FECH | CP | ENSBTAP00000008384 | ENSBTAP00000016137 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Ceruloplasmin; Belongs to the multicopper oxidase family. | 0.924 |
FECH | FDX2 | ENSBTAP00000008384 | ENSBTAP00000013630 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. | 0.551 |
FECH | FXN | ENSBTAP00000008384 | ENSBTAP00000001725 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity). | 0.992 |
FECH | HEPH | ENSBTAP00000008384 | ENSBTAP00000054213 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Hephaestin; Belongs to the multicopper oxidase family. | 0.940 |
FECH | HMOX1 | ENSBTAP00000008384 | ENSBTAP00000061215 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. | 0.964 |
FECH | HMOX2 | ENSBTAP00000008384 | ENSBTAP00000044292 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Heme oxygenase 2. | 0.973 |
FECH | ISCU | ENSBTAP00000008384 | ENSBTAP00000015648 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. | Iron-sulfur cluster scaffold homolog (E. coli); Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.775 |