STRINGSTRING
GHR protein (Bos taurus) - STRING interaction network
"GHR" - Growth hormone receptor in Bos taurus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GHRGrowth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily (634 aa)    
Predicted Functional Partners:
GH1
Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (217 aa)
       
  0.990
JAK2
Janus kinase 2 (1133 aa)
       
  0.984
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (229 aa)
         
  0.966
STAT5A
Signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity) (794 aa)
       
  0.960
PRLR
Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin (581 aa)
         
0.923
SH2B1
Bos taurus SH2B adaptor protein 1 (SH2B1), mRNA (756 aa)
         
  0.918
PRP1
Placental prolactin-related protein 1; Placental prolactin-related proteins may play a specific role during gestation (238 aa)
         
  0.918
PTPN1
Bos taurus protein tyrosine phosphatase, non-receptor type 1 (PTPN1), mRNA (425 aa)
     
    0.913
LYN
LYN proto-oncogene, Src family tyrosine kinase (512 aa)
       
  0.909
MAPK3
Mitogen-activated protein kinase 3 (362 aa)
     
 
  0.906
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
Server load: low (10%) [HD]