node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DUSP10 | MAP2K3 | ENSBTAP00000002265 | ENSBTAP00000071062 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase kinase 3. | 0.581 |
DUSP10 | MAPK1 | ENSBTAP00000002265 | ENSBTAP00000013623 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.938 |
DUSP10 | MAPK10 | ENSBTAP00000002265 | ENSBTAP00000026712 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.959 |
DUSP10 | MAPK11 | ENSBTAP00000002265 | ENSBTAP00000022358 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.905 |
DUSP10 | MAPK13 | ENSBTAP00000002265 | ENSBTAP00000013198 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.910 |
DUSP10 | MAPK14 | ENSBTAP00000002265 | ENSBTAP00000064750 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.905 |
DUSP10 | MAPK3 | ENSBTAP00000002265 | ENSBTAP00000021507 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.933 |
DUSP10 | MAPK8 | ENSBTAP00000002265 | ENSBTAP00000073182 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.582 |
DUSP10 | MAPK9 | ENSBTAP00000002265 | ENSBTAP00000061184 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Mitogen-activated protein kinase. | 0.564 |
DUSP10 | RPS6KA5 | ENSBTAP00000002265 | ENSBTAP00000014487 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | Ribosomal protein S6 kinase. | 0.564 |
MAP2K3 | DUSP10 | ENSBTAP00000071062 | ENSBTAP00000002265 | Mitogen-activated protein kinase kinase 3. | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.581 |
MAP2K3 | MAPK1 | ENSBTAP00000071062 | ENSBTAP00000013623 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.962 |
MAP2K3 | MAPK10 | ENSBTAP00000071062 | ENSBTAP00000026712 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase. | 0.918 |
MAP2K3 | MAPK11 | ENSBTAP00000071062 | ENSBTAP00000022358 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase. | 0.981 |
MAP2K3 | MAPK13 | ENSBTAP00000071062 | ENSBTAP00000013198 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] | 0.970 |
MAP2K3 | MAPK14 | ENSBTAP00000071062 | ENSBTAP00000064750 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase. | 0.979 |
MAP2K3 | MAPK3 | ENSBTAP00000071062 | ENSBTAP00000021507 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.973 |
MAP2K3 | MAPK8 | ENSBTAP00000071062 | ENSBTAP00000073182 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase. | 0.793 |
MAP2K3 | MAPK9 | ENSBTAP00000071062 | ENSBTAP00000061184 | Mitogen-activated protein kinase kinase 3. | Mitogen-activated protein kinase. | 0.705 |
MAPK1 | DUSP10 | ENSBTAP00000013623 | ENSBTAP00000002265 | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.938 |