HAND1 protein (Bos taurus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HAND1

Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (218 aa)

Predicted Functional Partners:

NKX2-5

0.662

GATA4

0.628

GCM1

0.581

PAG9

0.578

LOC528815

0.576

LOC521902

0.576

CDX2

0.571

GATA6

0.563

MESP1

0.550

ESX1

0.543

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDX2	GATA4	ENSBTAP00000044587	ENSBTAP00000007134	Homeobox domain-containing protein.	GATA binding protein 4.	0.754
CDX2	GATA6	ENSBTAP00000044587	ENSBTAP00000007537	Homeobox domain-containing protein.	GATA binding protein 6.	0.894
CDX2	GCM1	ENSBTAP00000044587	ENSBTAP00000010709	Homeobox domain-containing protein.	Glial cells missing transcription factor 1.	0.749
CDX2	HAND1	ENSBTAP00000044587	ENSBTAP00000003015	Homeobox domain-containing protein.	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	0.571
ESX1	HAND1	ENSBTAP00000007812	ENSBTAP00000003015	ESX homeobox 1.	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	0.543
GATA4	CDX2	ENSBTAP00000007134	ENSBTAP00000044587	GATA binding protein 4.	Homeobox domain-containing protein.	0.754
GATA4	GATA6	ENSBTAP00000007134	ENSBTAP00000007537	GATA binding protein 4.	GATA binding protein 6.	0.420
GATA4	HAND1	ENSBTAP00000007134	ENSBTAP00000003015	GATA binding protein 4.	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	0.628
GATA4	MESP1	ENSBTAP00000007134	ENSBTAP00000066585	GATA binding protein 4.	Mesoderm posterior bHLH transcription factor 1.	0.470
GATA4	NKX2-5	ENSBTAP00000007134	ENSBTAP00000027402	GATA binding protein 4.	NK2 transcription factor related, locus 5 (Drosophila).	0.966
GATA6	CDX2	ENSBTAP00000007537	ENSBTAP00000044587	GATA binding protein 6.	Homeobox domain-containing protein.	0.894
GATA6	GATA4	ENSBTAP00000007537	ENSBTAP00000007134	GATA binding protein 6.	GATA binding protein 4.	0.420
GATA6	HAND1	ENSBTAP00000007537	ENSBTAP00000003015	GATA binding protein 6.	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	0.563
GATA6	NKX2-5	ENSBTAP00000007537	ENSBTAP00000027402	GATA binding protein 6.	NK2 transcription factor related, locus 5 (Drosophila).	0.854
GCM1	CDX2	ENSBTAP00000010709	ENSBTAP00000044587	Glial cells missing transcription factor 1.	Homeobox domain-containing protein.	0.749
GCM1	HAND1	ENSBTAP00000010709	ENSBTAP00000003015	Glial cells missing transcription factor 1.	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	0.581
HAND1	CDX2	ENSBTAP00000003015	ENSBTAP00000044587	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	Homeobox domain-containing protein.	0.571
HAND1	ESX1	ENSBTAP00000003015	ENSBTAP00000007812	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	ESX homeobox 1.	0.543
HAND1	GATA4	ENSBTAP00000003015	ENSBTAP00000007134	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	GATA binding protein 4.	0.628
HAND1	GATA6	ENSBTAP00000003015	ENSBTAP00000007537	Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity).	GATA binding protein 6.	0.563

page 1 of 2

Server load: low (38%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2025

Credits

Access

Info

About