node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ETS1 | ETS2 | ENSBTAP00000059608 | ENSBTAP00000072496 | ETS proto-oncogene 1, transcription factor. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.924 |
ETS1 | JUN | ENSBTAP00000059608 | ENSBTAP00000005279 | ETS proto-oncogene 1, transcription factor. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.825 |
ETS1 | MAPK1 | ENSBTAP00000059608 | ENSBTAP00000013623 | ETS proto-oncogene 1, transcription factor. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.947 |
ETS1 | MAPK3 | ENSBTAP00000059608 | ENSBTAP00000021507 | ETS proto-oncogene 1, transcription factor. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.928 |
ETS1 | NFKB2 | ENSBTAP00000059608 | ENSBTAP00000007904 | ETS proto-oncogene 1, transcription factor. | Nuclear factor kappa B subunit 2. | 0.855 |
ETS1 | PAX5 | ENSBTAP00000059608 | ENSBTAP00000072830 | ETS proto-oncogene 1, transcription factor. | Paired box 5. | 0.906 |
ETS1 | RUNX1 | ENSBTAP00000059608 | ENSBTAP00000006224 | ETS proto-oncogene 1, transcription factor. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.992 |
ETS1 | RUNX3 | ENSBTAP00000059608 | ENSBTAP00000061160 | ETS proto-oncogene 1, transcription factor. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.789 |
ETS1 | SRF | ENSBTAP00000059608 | ENSBTAP00000016981 | ETS proto-oncogene 1, transcription factor. | Serum response factor. | 0.883 |
ETS1 | TP53 | ENSBTAP00000059608 | ENSBTAP00000001420 | ETS proto-oncogene 1, transcription factor. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.781 |
ETS2 | ETS1 | ENSBTAP00000072496 | ENSBTAP00000059608 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | ETS proto-oncogene 1, transcription factor. | 0.924 |
ETS2 | JUN | ENSBTAP00000072496 | ENSBTAP00000005279 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.684 |
ETS2 | MAPK1 | ENSBTAP00000072496 | ENSBTAP00000013623 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.924 |
ETS2 | MAPK3 | ENSBTAP00000072496 | ENSBTAP00000021507 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.917 |
ETS2 | NFKB2 | ENSBTAP00000072496 | ENSBTAP00000007904 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Nuclear factor kappa B subunit 2. | 0.557 |
ETS2 | PAX5 | ENSBTAP00000072496 | ENSBTAP00000072830 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Paired box 5. | 0.672 |
ETS2 | RUNX1 | ENSBTAP00000072496 | ENSBTAP00000006224 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.757 |
ETS2 | RUNX3 | ENSBTAP00000072496 | ENSBTAP00000061160 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.606 |
ETS2 | SRF | ENSBTAP00000072496 | ENSBTAP00000016981 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Serum response factor. | 0.865 |
ETS2 | TP53 | ENSBTAP00000072496 | ENSBTAP00000001420 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.772 |