| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CREBBP | ETS1 | ENSBTAP00000005092 | ENSBTAP00000059608 | CREB binding protein. | ETS proto-oncogene 1, transcription factor. | 0.874 |
| CREBBP | ETS2 | ENSBTAP00000005092 | ENSBTAP00000072496 | CREB binding protein. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.833 |
| CREBBP | JUN | ENSBTAP00000005092 | ENSBTAP00000005279 | CREB binding protein. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.964 |
| CREBBP | MAPK1 | ENSBTAP00000005092 | ENSBTAP00000013623 | CREB binding protein. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.633 |
| CREBBP | MAPK3 | ENSBTAP00000005092 | ENSBTAP00000021507 | CREB binding protein. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.621 |
| CREBBP | RUNX1 | ENSBTAP00000005092 | ENSBTAP00000006224 | CREB binding protein. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.806 |
| CREBBP | RUNX3 | ENSBTAP00000005092 | ENSBTAP00000061160 | CREB binding protein. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.750 |
| CREBBP | SRF | ENSBTAP00000005092 | ENSBTAP00000016981 | CREB binding protein. | Serum response factor. | 0.634 |
| CREBBP | TP53 | ENSBTAP00000005092 | ENSBTAP00000001420 | CREB binding protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.997 |
| ELK4 | ETS1 | ENSBTAP00000056094 | ENSBTAP00000059608 | ETS transcription factor ELK4. | ETS proto-oncogene 1, transcription factor. | 0.857 |
| ELK4 | ETS2 | ENSBTAP00000056094 | ENSBTAP00000072496 | ETS transcription factor ELK4. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.770 |
| ELK4 | JUN | ENSBTAP00000056094 | ENSBTAP00000005279 | ETS transcription factor ELK4. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.481 |
| ELK4 | MAPK1 | ENSBTAP00000056094 | ENSBTAP00000013623 | ETS transcription factor ELK4. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.922 |
| ELK4 | MAPK3 | ENSBTAP00000056094 | ENSBTAP00000021507 | ETS transcription factor ELK4. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.922 |
| ELK4 | SRF | ENSBTAP00000056094 | ENSBTAP00000016981 | ETS transcription factor ELK4. | Serum response factor. | 0.990 |
| ETS1 | CREBBP | ENSBTAP00000059608 | ENSBTAP00000005092 | ETS proto-oncogene 1, transcription factor. | CREB binding protein. | 0.874 |
| ETS1 | ELK4 | ENSBTAP00000059608 | ENSBTAP00000056094 | ETS proto-oncogene 1, transcription factor. | ETS transcription factor ELK4. | 0.857 |
| ETS1 | ETS2 | ENSBTAP00000059608 | ENSBTAP00000072496 | ETS proto-oncogene 1, transcription factor. | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity). | 0.982 |
| ETS1 | JUN | ENSBTAP00000059608 | ENSBTAP00000005279 | ETS proto-oncogene 1, transcription factor. | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. | 0.832 |
| ETS1 | MAPK1 | ENSBTAP00000059608 | ENSBTAP00000013623 | ETS proto-oncogene 1, transcription factor. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.977 |
