node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSBTAP00000062130 | LOC112446383 | ENSBTAP00000062130 | ENSBTAP00000073080 | Small ubiquitin-related modifier. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.873 |
ENSBTAP00000062130 | PIAS1 | ENSBTAP00000062130 | ENSBTAP00000071691 | Small ubiquitin-related modifier. | Protein inhibitor of activated STAT 1. | 0.937 |
ENSBTAP00000062130 | SAE1 | ENSBTAP00000062130 | ENSBTAP00000062557 | Small ubiquitin-related modifier. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.983 |
ENSBTAP00000062130 | SENP1 | ENSBTAP00000062130 | ENSBTAP00000070053 | Small ubiquitin-related modifier. | SUMO specific peptidase 1. | 0.968 |
ENSBTAP00000062130 | SUMO1 | ENSBTAP00000062130 | ENSBTAP00000066977 | Small ubiquitin-related modifier. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.412 |
ENSBTAP00000062130 | UBA2 | ENSBTAP00000062130 | ENSBTAP00000003333 | Small ubiquitin-related modifier. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.955 |
ENSBTAP00000062130 | UBE2I | ENSBTAP00000062130 | ENSBTAP00000059318 | Small ubiquitin-related modifier. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.797 |
ENSBTAP00000065305 | LOC112446383 | ENSBTAP00000065305 | ENSBTAP00000073080 | Uncharacterized protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.600 |
ENSBTAP00000065305 | PIAS1 | ENSBTAP00000065305 | ENSBTAP00000071691 | Uncharacterized protein. | Protein inhibitor of activated STAT 1. | 0.676 |
ENSBTAP00000065305 | SAE1 | ENSBTAP00000065305 | ENSBTAP00000062557 | Uncharacterized protein. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.891 |
ENSBTAP00000065305 | SENP1 | ENSBTAP00000065305 | ENSBTAP00000070053 | Uncharacterized protein. | SUMO specific peptidase 1. | 0.845 |
ENSBTAP00000065305 | SUMO1 | ENSBTAP00000065305 | ENSBTAP00000066977 | Uncharacterized protein. | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] | 0.800 |
ENSBTAP00000065305 | SUMO2 | ENSBTAP00000065305 | ENSBTAP00000040189 | Uncharacterized protein. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.547 |
ENSBTAP00000065305 | SUMO3 | ENSBTAP00000065305 | ENSBTAP00000023029 | Uncharacterized protein. | Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such [...] | 0.547 |
ENSBTAP00000065305 | UBA2 | ENSBTAP00000065305 | ENSBTAP00000003333 | Uncharacterized protein. | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. | 0.904 |
ENSBTAP00000065305 | UBE2I | ENSBTAP00000065305 | ENSBTAP00000059318 | Uncharacterized protein. | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | 0.916 |
LOC112446383 | ENSBTAP00000062130 | ENSBTAP00000073080 | ENSBTAP00000062130 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Small ubiquitin-related modifier. | 0.873 |
LOC112446383 | ENSBTAP00000065305 | ENSBTAP00000073080 | ENSBTAP00000065305 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Uncharacterized protein. | 0.600 |
LOC112446383 | PIAS1 | ENSBTAP00000073080 | ENSBTAP00000071691 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | Protein inhibitor of activated STAT 1. | 0.798 |
LOC112446383 | SAE1 | ENSBTAP00000073080 | ENSBTAP00000062557 | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. | SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family. | 0.917 |