node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHMP1A | CHMP2A | ENSBTAP00000044604 | ENSBTAP00000018429 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 2A. | 0.999 |
CHMP1A | CHMP3 | ENSBTAP00000044604 | ENSBTAP00000068505 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.996 |
CHMP1A | CHMP5 | ENSBTAP00000044604 | ENSBTAP00000016431 | Charged multivesicular body protein 1A. | Charged multivesicular body protein 5. | 0.984 |
CHMP1A | SNF8 | ENSBTAP00000044604 | ENSBTAP00000073037 | Charged multivesicular body protein 1A. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.841 |
CHMP1A | TM9SF1 | ENSBTAP00000044604 | ENSBTAP00000003509 | Charged multivesicular body protein 1A. | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.704 |
CHMP1A | VPS4A | ENSBTAP00000044604 | ENSBTAP00000055660 | Charged multivesicular body protein 1A. | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.996 |
CHMP1A | VPS4B | ENSBTAP00000044604 | ENSBTAP00000013862 | Charged multivesicular body protein 1A. | Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] | 0.995 |
CHMP2A | CHMP1A | ENSBTAP00000018429 | ENSBTAP00000044604 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 1A. | 0.999 |
CHMP2A | CHMP3 | ENSBTAP00000018429 | ENSBTAP00000068505 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | 0.986 |
CHMP2A | CHMP5 | ENSBTAP00000018429 | ENSBTAP00000016431 | Charged multivesicular body protein 2A. | Charged multivesicular body protein 5. | 0.985 |
CHMP2A | SNF8 | ENSBTAP00000018429 | ENSBTAP00000073037 | Charged multivesicular body protein 2A. | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.905 |
CHMP2A | TM9SF1 | ENSBTAP00000018429 | ENSBTAP00000003509 | Charged multivesicular body protein 2A. | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.752 |
CHMP2A | VPS4A | ENSBTAP00000018429 | ENSBTAP00000055660 | Charged multivesicular body protein 2A. | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.976 |
CHMP2A | VPS4B | ENSBTAP00000018429 | ENSBTAP00000013862 | Charged multivesicular body protein 2A. | Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] | 0.971 |
CHMP3 | CHMP1A | ENSBTAP00000068505 | ENSBTAP00000044604 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | Charged multivesicular body protein 1A. | 0.996 |
CHMP3 | CHMP2A | ENSBTAP00000068505 | ENSBTAP00000018429 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | Charged multivesicular body protein 2A. | 0.986 |
CHMP3 | CHMP5 | ENSBTAP00000068505 | ENSBTAP00000016431 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | Charged multivesicular body protein 5. | 0.973 |
CHMP3 | SNF8 | ENSBTAP00000068505 | ENSBTAP00000073037 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. | 0.838 |
CHMP3 | TM9SF1 | ENSBTAP00000068505 | ENSBTAP00000003509 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. | 0.812 |
CHMP3 | VPS4A | ENSBTAP00000068505 | ENSBTAP00000055660 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] | Uncharacterized protein; Belongs to the AAA ATPase family. | 0.943 |