node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPS5 | CUL1 | ENSBTAP00000003609 | ENSBTAP00000063991 | COP9 signalosome subunit 5. | Cullin 1; Belongs to the cullin family. | 0.824 |
COPS5 | CUL2 | ENSBTAP00000003609 | ENSBTAP00000070862 | COP9 signalosome subunit 5. | CUL2 protein; Belongs to the cullin family. | 0.896 |
COPS5 | CUL3 | ENSBTAP00000003609 | ENSBTAP00000029018 | COP9 signalosome subunit 5. | Cullin 3; Belongs to the cullin family. | 0.867 |
COPS5 | CUL5 | ENSBTAP00000003609 | ENSBTAP00000060422 | COP9 signalosome subunit 5. | Cullin 5; Belongs to the cullin family. | 0.545 |
COPS5 | NAE1 | ENSBTAP00000003609 | ENSBTAP00000013367 | COP9 signalosome subunit 5. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.719 |
COPS5 | NEDD8 | ENSBTAP00000003609 | ENSBTAP00000003514 | COP9 signalosome subunit 5. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.964 |
COPS5 | UBA3 | ENSBTAP00000003609 | ENSBTAP00000071509 | COP9 signalosome subunit 5. | Ubiquitin like modifier activating enzyme 3. | 0.793 |
COPS5 | UBE2F | ENSBTAP00000003609 | ENSBTAP00000036864 | COP9 signalosome subunit 5. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.644 |
COPS5 | UBE2M | ENSBTAP00000003609 | ENSBTAP00000067485 | COP9 signalosome subunit 5. | NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity). | 0.791 |
CUL1 | COPS5 | ENSBTAP00000063991 | ENSBTAP00000003609 | Cullin 1; Belongs to the cullin family. | COP9 signalosome subunit 5. | 0.824 |
CUL1 | CUL2 | ENSBTAP00000063991 | ENSBTAP00000070862 | Cullin 1; Belongs to the cullin family. | CUL2 protein; Belongs to the cullin family. | 0.568 |
CUL1 | CUL3 | ENSBTAP00000063991 | ENSBTAP00000029018 | Cullin 1; Belongs to the cullin family. | Cullin 3; Belongs to the cullin family. | 0.889 |
CUL1 | CUL5 | ENSBTAP00000063991 | ENSBTAP00000060422 | Cullin 1; Belongs to the cullin family. | Cullin 5; Belongs to the cullin family. | 0.658 |
CUL1 | NAE1 | ENSBTAP00000063991 | ENSBTAP00000013367 | Cullin 1; Belongs to the cullin family. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.887 |
CUL1 | NEDD8 | ENSBTAP00000063991 | ENSBTAP00000003514 | Cullin 1; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.985 |
CUL1 | SENP8 | ENSBTAP00000063991 | ENSBTAP00000007964 | Cullin 1; Belongs to the cullin family. | ULP_PROTEASE domain-containing protein. | 0.425 |
CUL1 | UBA3 | ENSBTAP00000063991 | ENSBTAP00000071509 | Cullin 1; Belongs to the cullin family. | Ubiquitin like modifier activating enzyme 3. | 0.916 |
CUL1 | UBE2F | ENSBTAP00000063991 | ENSBTAP00000036864 | Cullin 1; Belongs to the cullin family. | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. | 0.833 |
CUL1 | UBE2M | ENSBTAP00000063991 | ENSBTAP00000067485 | Cullin 1; Belongs to the cullin family. | NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity). | 0.982 |
CUL2 | COPS5 | ENSBTAP00000070862 | ENSBTAP00000003609 | CUL2 protein; Belongs to the cullin family. | COP9 signalosome subunit 5. | 0.896 |