node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERCC1 | EXO1 | ENSBTAP00000023078 | ENSBTAP00000012365 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | Exonuclease 1. | 0.788 |
ERCC1 | MLH1 | ENSBTAP00000023078 | ENSBTAP00000022288 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | MutL homolog 1. | 0.794 |
ERCC1 | MLH3 | ENSBTAP00000023078 | ENSBTAP00000053506 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | MutL homolog 3. | 0.659 |
ERCC1 | MSH2 | ENSBTAP00000023078 | ENSBTAP00000003556 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.954 |
ERCC1 | MSH3 | ENSBTAP00000023078 | ENSBTAP00000058894 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.847 |
ERCC1 | MSH6 | ENSBTAP00000023078 | ENSBTAP00000001867 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.867 |
ERCC1 | PMS1 | ENSBTAP00000023078 | ENSBTAP00000072141 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | PMS1 homolog 1, mismatch repair system component. | 0.763 |
ERCC1 | PMS2 | ENSBTAP00000023078 | ENSBTAP00000063916 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | Uncharacterized protein. | 0.800 |
ERCC1 | POLD1 | ENSBTAP00000023078 | ENSBTAP00000014714 | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.601 |
EXO1 | ERCC1 | ENSBTAP00000012365 | ENSBTAP00000023078 | Exonuclease 1. | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | 0.788 |
EXO1 | MLH1 | ENSBTAP00000012365 | ENSBTAP00000022288 | Exonuclease 1. | MutL homolog 1. | 0.985 |
EXO1 | MLH3 | ENSBTAP00000012365 | ENSBTAP00000053506 | Exonuclease 1. | MutL homolog 3. | 0.753 |
EXO1 | MSH2 | ENSBTAP00000012365 | ENSBTAP00000003556 | Exonuclease 1. | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] | 0.989 |
EXO1 | MSH3 | ENSBTAP00000012365 | ENSBTAP00000058894 | Exonuclease 1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.889 |
EXO1 | MSH6 | ENSBTAP00000012365 | ENSBTAP00000001867 | Exonuclease 1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.979 |
EXO1 | PCNA | ENSBTAP00000012365 | ENSBTAP00000007967 | Exonuclease 1. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.936 |
EXO1 | PMS1 | ENSBTAP00000012365 | ENSBTAP00000072141 | Exonuclease 1. | PMS1 homolog 1, mismatch repair system component. | 0.876 |
EXO1 | PMS2 | ENSBTAP00000012365 | ENSBTAP00000063916 | Exonuclease 1. | Uncharacterized protein. | 0.973 |
EXO1 | POLD1 | ENSBTAP00000012365 | ENSBTAP00000014714 | Exonuclease 1. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.908 |
MLH1 | ERCC1 | ENSBTAP00000022288 | ENSBTAP00000023078 | MutL homolog 1. | DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). | 0.794 |