node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASH2L | DPY30 | ENSBTAP00000001294 | ENSBTAP00000012183 | ASH2 like, histone lysine methyltransferase complex subunit. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | 0.999 |
ASH2L | EP300 | ENSBTAP00000001294 | ENSBTAP00000021556 | ASH2 like, histone lysine methyltransferase complex subunit. | E1A binding protein p300. | 0.615 |
ASH2L | HCFC1 | ENSBTAP00000001294 | ENSBTAP00000015793 | ASH2 like, histone lysine methyltransferase complex subunit. | Host cell factor C1. | 0.811 |
ASH2L | KMT2B | ENSBTAP00000001294 | ENSBTAP00000003584 | ASH2 like, histone lysine methyltransferase complex subunit. | Lysine methyltransferase 2B. | 0.920 |
ASH2L | KMT2D | ENSBTAP00000001294 | ENSBTAP00000066916 | ASH2 like, histone lysine methyltransferase complex subunit. | Lysine methyltransferase 2D. | 0.992 |
ASH2L | MEN1 | ENSBTAP00000001294 | ENSBTAP00000066214 | ASH2 like, histone lysine methyltransferase complex subunit. | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | 0.974 |
ASH2L | RBBP5 | ENSBTAP00000001294 | ENSBTAP00000021204 | ASH2 like, histone lysine methyltransferase complex subunit. | RB binding protein 5, histone lysine methyltransferase complex subunit. | 0.999 |
ASH2L | SETD1A | ENSBTAP00000001294 | ENSBTAP00000068889 | ASH2 like, histone lysine methyltransferase complex subunit. | SET domain containing 1A, histone lysine methyltransferase. | 0.964 |
ASH2L | SETD1B | ENSBTAP00000001294 | ENSBTAP00000022553 | ASH2 like, histone lysine methyltransferase complex subunit. | SET domain containing 1B, histone lysine methyltransferase. | 0.979 |
CREBBP | EP300 | ENSBTAP00000005092 | ENSBTAP00000021556 | CREB binding protein. | E1A binding protein p300. | 0.997 |
CREBBP | KMT2B | ENSBTAP00000005092 | ENSBTAP00000003584 | CREB binding protein. | Lysine methyltransferase 2B. | 0.807 |
CREBBP | KMT2D | ENSBTAP00000005092 | ENSBTAP00000066916 | CREB binding protein. | Lysine methyltransferase 2D. | 0.839 |
CREBBP | SETD1A | ENSBTAP00000005092 | ENSBTAP00000068889 | CREB binding protein. | SET domain containing 1A, histone lysine methyltransferase. | 0.407 |
CREBBP | SETD1B | ENSBTAP00000005092 | ENSBTAP00000022553 | CREB binding protein. | SET domain containing 1B, histone lysine methyltransferase. | 0.471 |
DPY30 | ASH2L | ENSBTAP00000012183 | ENSBTAP00000001294 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | ASH2 like, histone lysine methyltransferase complex subunit. | 0.999 |
DPY30 | HCFC1 | ENSBTAP00000012183 | ENSBTAP00000015793 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Host cell factor C1. | 0.607 |
DPY30 | KMT2B | ENSBTAP00000012183 | ENSBTAP00000003584 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Lysine methyltransferase 2B. | 0.819 |
DPY30 | KMT2D | ENSBTAP00000012183 | ENSBTAP00000066916 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Lysine methyltransferase 2D. | 0.731 |
DPY30 | MEN1 | ENSBTAP00000012183 | ENSBTAP00000066214 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] | 0.845 |
DPY30 | RBBP5 | ENSBTAP00000012183 | ENSBTAP00000021204 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem cells, may play a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (By similarity). | RB binding protein 5, histone lysine methyltransferase complex subunit. | 0.999 |