STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
WNT16Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (362 aa)    
Predicted Functional Partners:
PORCN
Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
 0.966
FZD6
Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.938
NOTUM
Notum, palmitoleoyl-protein carboxylesterase.
    
 0.931
GPC3
Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
    
 0.921
CER1
Cerberus 1, DAN family BMP antagonist.
   
 
 0.902
FZD2
Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.891
FZD3
Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.890
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.889
SFRP4
Secreted frizzled-related protein 4.
    
 0.887
DKK1
Dickkopf WNT signaling pathway inhibitor 1.
    
 0.874
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.