node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCZ1 | MON1A | ENSBTAP00000004259 | ENSBTAP00000026711 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | 0.986 |
CCZ1 | MON1B | ENSBTAP00000004259 | ENSBTAP00000058655 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Uncharacterized protein. | 0.981 |
CCZ1 | RAB7A | ENSBTAP00000004259 | ENSBTAP00000061056 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.956 |
CCZ1 | RMC1 | ENSBTAP00000004259 | ENSBTAP00000020214 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Regulator of MON1-CCZ1. | 0.976 |
CCZ1 | VPS11 | ENSBTAP00000004259 | ENSBTAP00000007042 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.986 |
CCZ1 | VPS16 | ENSBTAP00000004259 | ENSBTAP00000001744 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late [...] | 0.982 |
CCZ1 | VPS18 | ENSBTAP00000004259 | ENSBTAP00000015368 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | VPS18 core subunit of CORVET and HOPS complexes. | 0.982 |
CCZ1 | VPS33A | ENSBTAP00000004259 | ENSBTAP00000005508 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. | 0.916 |
CCZ1 | VPS39 | ENSBTAP00000004259 | ENSBTAP00000006949 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | VPS39 subunit of HOPS complex. | 0.986 |
CCZ1 | VPS41 | ENSBTAP00000004259 | ENSBTAP00000009615 | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.977 |
MON1A | CCZ1 | ENSBTAP00000026711 | ENSBTAP00000004259 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.986 |
MON1A | MON1B | ENSBTAP00000026711 | ENSBTAP00000058655 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | Uncharacterized protein. | 0.479 |
MON1A | RAB7A | ENSBTAP00000026711 | ENSBTAP00000061056 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] | 0.851 |
MON1A | RMC1 | ENSBTAP00000026711 | ENSBTAP00000020214 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | Regulator of MON1-CCZ1. | 0.540 |
MON1A | VPS11 | ENSBTAP00000026711 | ENSBTAP00000007042 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. | 0.489 |
MON1A | VPS18 | ENSBTAP00000026711 | ENSBTAP00000015368 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | VPS18 core subunit of CORVET and HOPS complexes. | 0.429 |
MON1A | VPS39 | ENSBTAP00000026711 | ENSBTAP00000006949 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | VPS39 subunit of HOPS complex. | 0.667 |
MON1A | VPS41 | ENSBTAP00000026711 | ENSBTAP00000009615 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. | 0.784 |
MON1B | CCZ1 | ENSBTAP00000058655 | ENSBTAP00000004259 | Uncharacterized protein. | Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. | 0.981 |
MON1B | MON1A | ENSBTAP00000058655 | ENSBTAP00000026711 | Uncharacterized protein. | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form. Belongs to the MON1/SAND family. | 0.479 |