STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MRPL58Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. (206 aa)    
Predicted Functional Partners:
MRPL21
39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family.
   
 
 0.997
GADD45GIP1
Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
   
 
 0.995
MRPL27
39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family.
  
 
 0.993
MRPL12
39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family.
  
 
 0.986
MRPL19
39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family.
  
 
 0.985
MRPL36
Ribosomal protein; Belongs to the bacterial ribosomal protein bL36 family.
   
 
 0.984
MRPS16
28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.
  
 
 0.983
MRPS7
28S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family.
  
 
 0.980
MRPL9
39S ribosomal protein L9, mitochondrial.
  
 
 0.977
MRPL32
39S ribosomal protein L32, mitochondrial; Belongs to the bacterial ribosomal protein bL32 family.
  
 
 0.976
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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