node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACER1 | ACER2 | ENSBTAP00000010648 | ENSBTAP00000014354 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.914 |
ACER1 | ACER3 | ENSBTAP00000010648 | ENSBTAP00000051467 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.599 |
ACER1 | ASAH1 | ENSBTAP00000010648 | ENSBTAP00000014960 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.981 |
ACER1 | ASAH2 | ENSBTAP00000010648 | ENSBTAP00000004585 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase. | 0.986 |
ACER1 | CERS4 | ENSBTAP00000010648 | ENSBTAP00000004459 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide synthase 4; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. | 0.971 |
ACER1 | DEGS1 | ENSBTAP00000010648 | ENSBTAP00000016887 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.939 |
ACER1 | DEGS2 | ENSBTAP00000010648 | ENSBTAP00000012243 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | 0.962 |
ACER1 | SGMS1 | ENSBTAP00000010648 | ENSBTAP00000065438 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingomyelin synthase 1. | 0.964 |
ACER1 | SGPP1 | ENSBTAP00000010648 | ENSBTAP00000005808 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine-1-phosphate phosphatase 1. | 0.917 |
ACER1 | SPHK2 | ENSBTAP00000010648 | ENSBTAP00000067621 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine kinase 2. | 0.973 |
ACER2 | ACER1 | ENSBTAP00000014354 | ENSBTAP00000010648 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.914 |
ACER2 | ACER3 | ENSBTAP00000014354 | ENSBTAP00000051467 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.554 |
ACER2 | ASAH1 | ENSBTAP00000014354 | ENSBTAP00000014960 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.976 |
ACER2 | ASAH2 | ENSBTAP00000014354 | ENSBTAP00000004585 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase. | 0.988 |
ACER2 | CERS4 | ENSBTAP00000014354 | ENSBTAP00000004459 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide synthase 4; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. | 0.973 |
ACER2 | DEGS1 | ENSBTAP00000014354 | ENSBTAP00000016887 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) (By similarity); Belongs to the fatty acid desaturase type 1 family. DEGS subfamily. | 0.960 |
ACER2 | DEGS2 | ENSBTAP00000014354 | ENSBTAP00000012243 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. | 0.953 |
ACER2 | SGMS1 | ENSBTAP00000014354 | ENSBTAP00000065438 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingomyelin synthase 1. | 0.968 |
ACER2 | SGPP1 | ENSBTAP00000014354 | ENSBTAP00000005808 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine-1-phosphate phosphatase 1. | 0.926 |
ACER2 | SPHK2 | ENSBTAP00000014354 | ENSBTAP00000067621 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine kinase 2. | 0.972 |