node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | BGN | ENSBTAP00000021512 | ENSBTAP00000044462 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Biglycan; May be involved in collagen fiber assembly. | 0.912 |
ACAN | COL3A1 | ENSBTAP00000021512 | ENSBTAP00000028617 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen alpha-1(III) chain. | 0.551 |
ACAN | DCN | ENSBTAP00000021512 | ENSBTAP00000004562 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.953 |
ACAN | IGF1 | ENSBTAP00000021512 | ENSBTAP00000055243 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.720 |
ACAN | LUM | ENSBTAP00000021512 | ENSBTAP00000002279 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.866 |
ACAN | TGFB1 | ENSBTAP00000021512 | ENSBTAP00000064484 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.798 |
ACAN | TLR4 | ENSBTAP00000021512 | ENSBTAP00000008190 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding t [...] | 0.454 |
BGN | ACAN | ENSBTAP00000044462 | ENSBTAP00000021512 | Biglycan; May be involved in collagen fiber assembly. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.912 |
BGN | COL3A1 | ENSBTAP00000044462 | ENSBTAP00000028617 | Biglycan; May be involved in collagen fiber assembly. | Collagen alpha-1(III) chain. | 0.798 |
BGN | DCN | ENSBTAP00000044462 | ENSBTAP00000004562 | Biglycan; May be involved in collagen fiber assembly. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.969 |
BGN | IGF1 | ENSBTAP00000044462 | ENSBTAP00000055243 | Biglycan; May be involved in collagen fiber assembly. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.761 |
BGN | LUM | ENSBTAP00000044462 | ENSBTAP00000002279 | Biglycan; May be involved in collagen fiber assembly. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.737 |
BGN | TGFB1 | ENSBTAP00000044462 | ENSBTAP00000064484 | Biglycan; May be involved in collagen fiber assembly. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.882 |
BGN | TLR2 | ENSBTAP00000044462 | ENSBTAP00000010530 | Biglycan; May be involved in collagen fiber assembly. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.966 |
BGN | TLR4 | ENSBTAP00000044462 | ENSBTAP00000008190 | Biglycan; May be involved in collagen fiber assembly. | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS- independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding t [...] | 0.876 |
COL3A1 | ACAN | ENSBTAP00000028617 | ENSBTAP00000021512 | Collagen alpha-1(III) chain. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.551 |
COL3A1 | BGN | ENSBTAP00000028617 | ENSBTAP00000044462 | Collagen alpha-1(III) chain. | Biglycan; May be involved in collagen fiber assembly. | 0.798 |
COL3A1 | DCN | ENSBTAP00000028617 | ENSBTAP00000004562 | Collagen alpha-1(III) chain. | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. | 0.953 |
COL3A1 | IGF1 | ENSBTAP00000028617 | ENSBTAP00000055243 | Collagen alpha-1(III) chain. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.498 |
COL3A1 | LUM | ENSBTAP00000028617 | ENSBTAP00000002279 | Collagen alpha-1(III) chain. | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. | 0.954 |