node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDHD2 | LSM1 | ENSBTAP00000017473 | ENSBTAP00000002113 | DDHD domain containing 2. | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | 0.707 |
DDHD2 | PLPBP | ENSBTAP00000017473 | ENSBTAP00000039600 | DDHD domain containing 2. | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.724 |
DDHD2 | TM2D2 | ENSBTAP00000017473 | ENSBTAP00000004567 | DDHD domain containing 2. | TM2 domain-containing protein 2. | 0.747 |
FAM110A | PLEKHA2 | ENSBTAP00000011392 | ENSBTAP00000068621 | Protein FAM110A; Belongs to the FAM110 family. | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.694 |
FAM110A | TM2D2 | ENSBTAP00000011392 | ENSBTAP00000004567 | Protein FAM110A; Belongs to the FAM110 family. | TM2 domain-containing protein 2. | 0.723 |
FAM110A | ZMAT4 | ENSBTAP00000011392 | ENSBTAP00000044561 | Protein FAM110A; Belongs to the FAM110 family. | Zinc finger matrin-type protein 4. | 0.670 |
LAMTOR2 | NHLRC2 | ENSBTAP00000045185 | ENSBTAP00000004806 | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | NHL repeat-containing protein 2; Required for normal embryonic development. | 0.805 |
LAMTOR2 | TM2D1 | ENSBTAP00000045185 | ENSBTAP00000022805 | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | TM2 domain containing 1. | 0.540 |
LAMTOR2 | TM2D2 | ENSBTAP00000045185 | ENSBTAP00000004567 | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | TM2 domain-containing protein 2. | 0.654 |
LSM1 | DDHD2 | ENSBTAP00000002113 | ENSBTAP00000017473 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | DDHD domain containing 2. | 0.707 |
LSM1 | PLEKHA2 | ENSBTAP00000002113 | ENSBTAP00000068621 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | 0.485 |
LSM1 | PLPBP | ENSBTAP00000002113 | ENSBTAP00000039600 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.743 |
LSM1 | TM2D2 | ENSBTAP00000002113 | ENSBTAP00000004567 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | TM2 domain-containing protein 2. | 0.678 |
NHLRC2 | LAMTOR2 | ENSBTAP00000004806 | ENSBTAP00000045185 | NHL repeat-containing protein 2; Required for normal embryonic development. | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.805 |
NHLRC2 | TM2D1 | ENSBTAP00000004806 | ENSBTAP00000022805 | NHL repeat-containing protein 2; Required for normal embryonic development. | TM2 domain containing 1. | 0.748 |
NHLRC2 | TM2D2 | ENSBTAP00000004806 | ENSBTAP00000004567 | NHL repeat-containing protein 2; Required for normal embryonic development. | TM2 domain-containing protein 2. | 0.823 |
PLEKHA2 | FAM110A | ENSBTAP00000068621 | ENSBTAP00000011392 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Protein FAM110A; Belongs to the FAM110 family. | 0.694 |
PLEKHA2 | LSM1 | ENSBTAP00000068621 | ENSBTAP00000002113 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). | 0.485 |
PLEKHA2 | PLPBP | ENSBTAP00000068621 | ENSBTAP00000039600 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6. | 0.459 |
PLEKHA2 | TM2D2 | ENSBTAP00000068621 | ENSBTAP00000004567 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity). | TM2 domain-containing protein 2. | 0.792 |