| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATOH7 | POU4F2 | ENSBTAP00000023292 | ENSBTAP00000007421 | Atonal bHLH transcription factor 7. | POU domain protein. | 0.852 |
| ATOH7 | SNCG | ENSBTAP00000023292 | ENSBTAP00000071939 | Atonal bHLH transcription factor 7. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.665 |
| FAM25A | SNCG | ENSBTAP00000023860 | ENSBTAP00000071939 | Uncharacterized protein. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.621 |
| FEM1C | NRN1 | ENSBTAP00000011464 | ENSBTAP00000013021 | Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family. | Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. | 0.637 |
| FEM1C | SNCG | ENSBTAP00000011464 | ENSBTAP00000071939 | Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.603 |
| MYOC | SNCG | ENSBTAP00000027111 | ENSBTAP00000071939 | Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.655 |
| NRN1 | FEM1C | ENSBTAP00000013021 | ENSBTAP00000011464 | Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. | Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family. | 0.637 |
| NRN1 | SNCG | ENSBTAP00000013021 | ENSBTAP00000071939 | Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.665 |
| POU4F2 | ATOH7 | ENSBTAP00000007421 | ENSBTAP00000023292 | POU domain protein. | Atonal bHLH transcription factor 7. | 0.852 |
| POU4F2 | SNCG | ENSBTAP00000007421 | ENSBTAP00000071939 | POU domain protein. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.606 |
| RBPMS | SNCG | ENSBTAP00000067085 | ENSBTAP00000071939 | RNA binding protein, mRNA processing factor. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.651 |
| SNCA | SNCAIP | ENSBTAP00000021300 | ENSBTAP00000071434 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Synuclein alpha interacting protein. | 0.991 |
| SNCA | SNCB | ENSBTAP00000021300 | ENSBTAP00000012928 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.584 |
| SNCA | SNCG | ENSBTAP00000021300 | ENSBTAP00000071939 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.689 |
| SNCAIP | SNCA | ENSBTAP00000071434 | ENSBTAP00000021300 | Synuclein alpha interacting protein. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.991 |
| SNCAIP | SNCG | ENSBTAP00000071434 | ENSBTAP00000071939 | Synuclein alpha interacting protein. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.627 |
| SNCB | SNCA | ENSBTAP00000012928 | ENSBTAP00000021300 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.584 |
| SNCB | SNCG | ENSBTAP00000012928 | ENSBTAP00000071939 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.859 |
| SNCG | ATOH7 | ENSBTAP00000071939 | ENSBTAP00000023292 | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | Atonal bHLH transcription factor 7. | 0.665 |
| SNCG | FAM25A | ENSBTAP00000071939 | ENSBTAP00000023860 | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | Uncharacterized protein. | 0.621 |