STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NHLRC2NHL repeat-containing protein 2; Required for normal embryonic development. (726 aa)    
Predicted Functional Partners:
TM2D2
TM2 domain-containing protein 2.
      
 0.823
LAMTOR2
Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...]
      
 0.805
CCDC186
Coiled-coil domain containing 186.
   
  
 0.794
TM2D3
TM2 domain containing 3.
      
 0.790
NAA30
N(alpha)-acetyltransferase 30, NatC catalytic subunit.
   
  
 0.750
TM2D1
TM2 domain containing 1.
      
 0.748
CDADC1
Cytidine and dCMP deaminase domain containing 1.
   
  
 0.712
VWA2
Von Willebrand factor A domain containing 2.
    
 
 0.696
TMEM131
Transmembrane protein 131.
      
 0.689
ATP13A1
Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
    
 
 0.676
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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